Journal of Pediatric and Adolescent Gynecology
Volume 19, Issue 3 , Pages 195-204 , June 2006

Vulvar Ulcers in Young Females: A Manifestation of Aphthosis

  • Jill S. Huppert, MD, MPH

      Affiliations

    • Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • Corresponding Author InformationAddress correspondence to: Jill S. Huppert, MD, MPH, Cincinnati Children's Hospital Medical Center, Division of Adolescent Medicine, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229-3039
    • ,
  • Michael A. Gerber, MD

      Affiliations

    • Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Helen R. Deitch, MD

      Affiliations

    • Department of OBGYN, Pennsylvania State University, State College, Pennsylvania, USA
    • ,
  • Joel E. Mortensen, PhD

      Affiliations

    • Division of Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Mary Allen Staat, MD, MPH

      Affiliations

    • Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Paula J. Adams Hillard, MD

      Affiliations

    • Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

References 

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  2. Margesson L: Pediatric vulvar disorders. In: Obstetric and Gynecologic Dermatolgy, (2nd ed). Edited by M Black, M Mckay, P Braude, S Vaughan Jones, I Margesson. London, Mosby; 2002, pp 119–135
  3. Brown ZA, Stenchever MA. Genital ulceration and infectious mononucleosis: report of a case. Am J Obstet Gynecol. 1977;127:673
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  6. Taylor S, Drake SM, Dedicoat M, et al. Genital ulcers associated with acute Epstein-Barr virus infection. Sex Transm Infect. 1998;74:296
  7. Hudson LB, Perlman SE. Necrotizing genital ulcerations in a premenarcheal female with mononucleosis. Obstet Gynecol. 1998;92(4 Pt 2):642
  8. Deitch HR, Huppert J, Adams Hillard PJ. Unusual vulvar ulcerations in young adolescent females. J Pediatr Adolesc Gynecol. 2004;17:13
  9. Sakane T, Takeno M, Suzuki N, et al. Behcet's disease. N Engl J Med. 1999;341:1284
  10. McKay M: Differential diagnosis of the vulvar ulcer, Appendix A. In: Obstetric and Gynecologic Dermatology, (2nd ed). Edited by M Black, M Mckay, P Braude, S Vaughan Jones, I Margesson. London, Mosby; 2002. pp 187–207
  11. Kaufman R: Miscellaneous vulvar disorders. In: Benign Diseases of the Vulva and Vagina, (5th ed.). Edited by R Kaufman, S Faro, D Brown. Philadelhia, Elsevier Mosby, 2005. pp 298–305
  12. Shulman JD. An exploration of point, annual, and lifetime prevalence in characterizing recurrent aphthous stomatitis in USA children and youths. J Oral Pathol Med. 2004;33:558
  13. Zunt SL. Recurrent aphthous stomatitis. Dermatol Clin. 2003;21:33
  14. McCarty MA, Garton RA, Jorizzo JL. Complex aphthosis and Behcet's disease. Dermatol Clin. 2003;21:41
  15. Centers for Disease Control and Prevention . Sexually Transmitted Diseases Treatment Guidelines 2002. MMWR. 2002;51:30
  16. Lipschutz B. Uber eine eigenartige Geschwursform des weiblichen Genitales (Ulcus vulvae actum). Arch Dermatol Syph (Berlin). 1913;114:363
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  18. Abulafia O, DuBeshter B, Dawson AE, et al. Presence of cytomegalovirus inclusion bodies in a recurrent ulcerative vaginal lesion. Am J Obstet Gynecol. 1993;169:1179
  19. Pelletier F, Aubin F, Puzenat E, et al. Lipschutz genital ulceration: a rare manifestation of paratyphoid fever. Eur J Dermatol. 2003;13:297
  20. Moghadam BK, Hersini S, Barker BF. Autoimmune progesterone dermatitis and stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:537
  21. Wintzen M, Goor-van Egmond MB, Noz KC. Autoimmune progesterone dermatitis presenting with purpura and petechiae. Clin Exp Dermatol. 2004;29:316
  22. Halevy S, Cohen AD, Lunenfeld E, et al. Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: Confirmation of progesterone sensitivity by in vitro interferon-gamma release. J Am Acad Dermatol. 2002;47:311
  23. Phy JL, Weiss WT, Weiler CR, et al. Hypersensitivity to progesterone-in-oil after in vitro fertilization and embryo transfer. Fertil Steril. 2003;80:1272
  24. Tsao H, Lerner LH. Pigmented purpuric eruption associated with injection medroxyprogesterone acetate. J Am Acad Dermatol. 2000;43(2 Pt 1):308
  25. Healy CM, Thornhill MH. An association between recurrent oro-genital ulceration and non-steroidal anti-inflammatory drugs. J Oral Pathol Med. 1995;24:46
  26. International Study Group for Behcet's Disease . Criteria for diagnosis of Behcet's disease. Lancet. 1990;335:1078
  27. Singer AJ, Stark MJ. LET versus EMLA for pretreating lacerations: a randomized trial. Acad Emerg Med. 2001;8:223
  28. Binnie WH, Curro FA, Khandwala A, et al. Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers. Compend Contin Educ Dent. 1997;8:1116
  29. Kerr AR, Drexel CA, Spielman AI. The efficacy and safety of 50 mg penicillin G potassium troches for recurrent aphthous ulcers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:685

PII: S1083-3188(06)00071-4

doi: 10.1016/j.jpag.2006.02.006

Journal of Pediatric and Adolescent Gynecology
Volume 19, Issue 3 , Pages 195-204 , June 2006

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