Journal of Pediatric and Adolescent Gynecology
Volume 19, Issue 5 , Pages 337-339 , October 2006

Significance of Topical Estrogens to Labial Fusion and Vaginal Introital Integrity

  • Justine Schober, MD

      Affiliations

    • Hamot Medical Center, Erie, Pennsylvania
    • Corresponding Author InformationAddress correspondence to: Justine Schober, MD, 333 State Street, Suite 201, Erie, PA 16507
    • ,
  • Lori Dulabon, DO

      Affiliations

    • Syracuse University, Syracuse, New York
    • ,
  • Nieves Martin-Alguacil, DVM, PhD

      Affiliations

    • Department of Neurobiology and Behavior, The Rockefeller University, New York, New York
    • Department of Anatomy and Embriology, School of Veterinary Medicine, Universidad Complutense de Madrid, Spain
    • ,
  • Lee-Ming Kow, PhD

      Affiliations

    • Department of Neurobiology and Behavior, The Rockefeller University, New York, New York
    • ,
  • Donald Pfaff, PhD

      Affiliations

    • Department of Neurobiology and Behavior, The Rockefeller University, New York, New York

References 

  1. Leung AK, Robson WL, Tay-Uyboco J. The incidence of labial fusion in children. J Paediatr Child Health. 1993;29:235
  2. Bacon JL. Prepubertal labial adhesions: evaluation of a referral population. Am J Obstet Gynecol. 2002;187:327
  3. Passamaneck M, Koyle M. Betamethasone treatment for separation of labial fusion. [Abstracts of the ESPU-AAP] J Ped Urol. 2005;1:107
  4. Muram D. Treatment of prepubertal girls with labial adhesions. J Pediatr Adolesc Gynecol. 1999;12:67
  5. Kumar RK, Sonika A, Charu C, et al. Labial adhesions in pubertal girls. Arch Gynecol Obstet. 2006;273:243
  6. Julia J, Yacoub M, Levy G. Labial fusion causing urinary incontinence in a postmenopausal female: a case report. Int Urogynecol J Pelvic Floor Dysfunct. 2003;14:360
  7. Lambert B. Complete adult vulvar fusion: a case report. J Obstet Gynaecol Can. 2004;26:501
  8. Maheux R, Naud F, Rioux M, et al. A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol. 1994;170:642
  9. Lubahn DB, Moyer JS, Golding TS, et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A. 1993;90:11162
  10. McLean JM: Anatomy and physiology of the vulval area. In: The Vulva. Edited by CM Ridley. London, Churchill Livingstone, 1988
  11. Papagianni M, Stanhope R. Labial adhesions in a girl with isolated premature thelarche: the importance of estrogenization. J Pediatr Adolesc Gynecol. 2003;16:31
  12. Press MF, Nousek-Goebl NA, Bur M, et al. Estrogen receptor localization in the female genital tract. Am J Pathol. 1986;123:280
  13. Schmidt JB, Lindmaier A, Spona J. Hormone receptors in pubic skin of premenopausal and postmenopausal females. Gynecol Obstet Invest. 1990;30:97
  14. Ashcroft GS, Mills SJ, Lei K, et al. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest. 2003;111:1309
  15. Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev. 2004;25:205
  16. Buchanan DL, Kurita T, Taylor JA, et al. Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification, and cornification. Endocrinology. 1998;139:4345

PII: S1083-3188(06)00185-9

doi: 10.1016/j.jpag.2006.06.004

Journal of Pediatric and Adolescent Gynecology
Volume 19, Issue 5 , Pages 337-339 , October 2006

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