Journal of Pediatric and Adolescent Gynecology
Volume 20, Issue 2 , Pages 67-72 , April 2007

Normal Ovarian Structure and Function with Normal Glucose Tolerance in Girls with Early Treatment of Classic Congenital Adrenal Hyperplasia

  • Amy Fleischman

      Affiliations

    • Division of Endocrinology, Department of Medicine, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA
    • Corresponding Author InformationAddress correspondence to: Amy Fleischman, MD, MMSc, Children's Hospital Boston, Division of Endocrinology, 333 Longwood Avenue, Boston, MA 02115
    • ,
  • Harriet Paltiel

      Affiliations

    • Department of Radiology, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA
    • ,
  • Jeanne Chow

      Affiliations

    • Department of Radiology, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA
    • ,
  • Julie Ringelheim

      Affiliations

    • Division of Adolescent and Young Adult Medicine, Department of Medicine, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA
    • ,
  • Catherine M. Gordon

      Affiliations

    • Division of Endocrinology, Department of Medicine, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA
    • Division of Adolescent and Young Adult Medicine, Department of Medicine, Children's Hospital Boston, MA, Harvard Medical School, Boston, Massachusetts, USA

References 

  1. Speiser PW, White PC. Congenital adrenal hyperplasia. N Engl J Med. 2003;349:776
  2. Migeon CJ, Wisniewski AB. Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency. Growth, development, and therapeutic considerations. Endocrinol Metab Clin North Am. 2001;30:193
  3. Zawadsku JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Blackwell Scientific Publications; 1992;
  4. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group . Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41
  5. Legro RS, Kunselman AR, Dodson WC, et al. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999;84:165
  6. Palmert MR, Gordon CM, Kartashov AI, et al. Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:1017
  7. Dunaif A, Segal KR, Futterweit W, et al. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 1989;38:1165
  8. Ibanez L, de Zegher F, Potau N. Premature pubarche, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset. J Endocrinol Invest. 1998;21:558
  9. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412
  10. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23:57
  11. Orsini LF, Salardi S, Pilu G, et al. Pelvic organs in premenarcheal girls: real-time ultrasonography. Radiology. 1984;153:113
  12. Cohen HL, Tice HM, Mandel FS. Ovarian volumes measured by US: bigger than we think. Radiology. 1990;177:189
  13. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2005;28(Suppl 1):S37
  14. Uwaifo GI, Fallon EM, Chin J, et al. Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care. 2002;25:2081
  15. Hague WM, Adams J, Rodda C, et al. The prevalence of polycystic ovaries in patients with congenital adrenal hyperplasia and their close relatives. Clin Endocrinol (Oxf). 1990;33:501
  16. Salardi S, Orsini LF, Cacciari E, et al. Pelvic ultrasonography in girls with precocious puberty, congenital adrenal hyperplasia, obesity, or hirsutism. J Pediatr. 1988;112:880
  17. Stikkelbroeck NM, Hermus AR, Schouten D, et al. Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging. Eur Radiol. 2004;14:1802
  18. Barnes RB, Rosenfield RL, Ehrmann DA, et al. Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab. 1994;79:1328
  19. Paula FJ, Gouveia LM, Paccola GM, et al. Androgen-related effects on peripheral glucose metabolism in women with congenital adrenal hyperplasia. Horm Metab Res. 1994;26:552
  20. Charmandari E, Weise M, Bornstein SR, et al. Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications. J Clin Endocrinol Metab. 2002;87:2114

 Funding: This project was supported by an investigator initiated grant from Pfizer, Inc., and the Clinical Investigator Training Program: Harvard-MIT Health Sciences and Technology—Beth Israel Deaconess Medical Center, in collaboration with Pfizer Inc. and Merck & Company, Inc., and Nitt grant M01-RR-2172 from the National Institutes of Health to Children's Hospital Boston General Clinical Research Center.

PII: S1083-3188(06)00273-7

doi: 10.1016/j.jpag.2006.08.001

Journal of Pediatric and Adolescent Gynecology
Volume 20, Issue 2 , Pages 67-72 , April 2007

Article Tools

* Image Usage & Resolution