Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 5 , Pages e99-e103, October 2009

Occurrence of Two Rare Malignant Neoplasms (Breast and Ovarian) in an Adolescent Female

  • Yasmin Jayasinghe, MBBS
    • ,
  • Patricia S. Simmons, MD

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Patricia S. Simmons, MD, Department of Pediatric & Adolescent Medicine, Mayo Clinic, 200 First St SW, Rochester MN 55905

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA

published online 09 April 2009.

Abstract 

Background

Phyllodes breast tumors, particularly malignant ones, are rare in adolescents. Tumor behavior does not correlate with histopathology. This case of an adolescent with a malignant phyllodes tumor, followed by the occurrence of a borderline ovarian tumor, also uncommon in adolescence, may shed light on our understanding of phyllodes and uncommon gynecologic malignancies in the young.

Case

A-14 year-old Caucasian female underwent wide local excision of a 4-cm malignant phyllodes breast tumor. At 17 years of age she had excision of a serous borderline tumor of the ovary.

Comments

The occurrence of two rare neoplasms in an adolescent female raises questions about a common underlying etiology, such as a genetic mutation. Genetic evaluation of minors is a sensitive and complex issue. Natural history studies regarding phyllodes tumors presenting in adolescence are needed to establish recommendations regarding best practice, including the role of genetic evaluation in this population.

Key Words: Phyllodes, Borderline ovarian tumor, Adolescent, p53, Breast tumor

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 This paper was presented in part at the North American Society for Pediatric & Adolescent Gynecology Annual Meeting in Orlando, Florida, May 2006.

PII: S1083-3188(06)00338-X

doi:10.1016/j.jpag.2006.11.005

Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 5 , Pages e99-e103, October 2009

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