Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 3 , Pages 173-179 , June 2009

No Activating Mutations of FSH Receptor in Four Children with Ovarian Juvenile Granulosa Cell Tumors and the Association of These Tumors with Central Precocious Puberty

  • Firdevs Bas

      Affiliations

    • Associate Professor, Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
    • Corresponding Author InformationAddress correspondence to: Firdevs Bas, Istanbul Tıp Fakültesi, Çocuk Kliniği, Çapa 34390, Istanbul, Turkey
  • ,
  • Ora Hirsch Pescovitz

      Affiliations

    • Professor, Section of Pediatric Endocrinology and Diabetology, Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
  • ,
  • Rosemary Steinmetz

      Affiliations

    • Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA

References 

  1. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary: A clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984;8:575
  2. Zaloudek C, Norris HJ. Granulosa tumors of the ovary in children: A clinical and pathologic study of 32 cases. Am J Surg Pathol. 1982;6:513
  3. Lack EE, Young RH, Scully RE. Pathology of ovarian neoplasms in childhood and adolescence. Path Annu. 1992;27:281
  4. Cronje HS, Niemand I, Bam RH, et al. Granulosa and theca cell tumors in children: A report of 17 cases and literature review. Obstet Gynecol Surv. 1998;53:240
  5. Biscotti CV, Hart WR. Juvenile granulosa cell tumors of the ovary. Arch Pathol Lab Med. 1989;113:40
  6. Norris HJ, Jensen RD. Relative frequency of neoplasm in children and adolescents. Cancer. 1972;30:713
  7. Vassal G, Flamant F, Caillaud JM, et al. Juvenile granulosa cell tumor of the ovary in children: A clinical study of 15 cases. J Clin Oncol. 1988;6:990
  8. Calaminus G, Wessalowski R, Harms D, et al. Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study. Gynecol Oncol. 1997;65:447
  9. Dengg K, Fink FM, Heitger A, et al. Precocious puberty due to a lipid cell tumor of the ovary. Eur J Pediatr. 1993;152:12
  10. Kukuvitis A, Matte C, Polychronakos C. Central precocious puberty following feminizing right ovarian granulosa cell tumor. Horm Res. 1995;44:268
  11. Feilberg Jorgensen N, Brock Jacobsen B, Ahrons S, et al. An association of hypothalamic hamartoma, central precocious puberty and juvenile granulosa cell tumor in early childhood. Horm Res. 1998;49:292
  12. Rossing MA, Daling JR, Weiss NS, et al. Ovarian tumors in a cohort of infertile women. N Engl J Med. 1994;331:771
  13. Willemsen W, Kruitwagen R, Bastiaans B, et al. Ovarian stimulation and granulosa cell tumour. Lancet. 1993;341:986
  14. Simoni M, Gromoll J, Nieschlag E. The follicle stimulating hormone receptor: Biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev. 1997;18:739
  15. Kotlar TJ, Young RH, Albanese C, et al. A mutation in the follicle stimulating hormone receptor occurs frequently in human ovarian sex cord tumors. J Clin Endocrinol Metab. 1997;82:1020
  16. Fuller PJ, Verity K, Shen Y, et al. No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors. J Clin Endocrinol Metab. 1998;83:274
  17. Ligtenberg MJ, Siers M, Themmen APN, et al. Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors. J Clin Endocrinol Metab. 1999;84:2233
  18. Marshall WA, Tanner JM. Variation in pattern of pubertal changes in girls. Arch Dis Child. 1969;44:291
  19. Neyzi O, Binyildiz P, Alp H. Growth standards for Turkish children. Courrier. 1979;29:553
  20. Stouffer RL, Grodin MS, Davis JR, et al. Investigation of binding sites for follicle-stimulating hormone and chorionic gonadotropin in human ovarian cancers. J Clin Endocrinol Metab. 1984;59:441
  21. Nakano R, Kitayama S, Yamoto M, et al. Localization of gonadotropin binding sites in human ovarian neoplasms. Am J Obstet Gynecol. 1989;161:905
  22. Villares- Fragoso MCB, Latronico AC, Carvalho FM, et al. Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. J Clin Endocrinol Metab. 1998;83:2074
  23. Chan WY. Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations. Mol Genet Metab. 1998;63:74
  24. Minegish T, Nakamura K, Takakura Y, et al. Cloning and sequencing of human FSH receptor cDNA. Biochem Biophys Res Commun. 1991;175:1125
  25. Kelton CA, Cheng SVY, Nugent NP, et al. The cloning of the human follicle-stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells. Mol and Cell Endocrinol. 1992;89:141
  26. Aittomaki K, Diequez Lucena JL, Pakarinen P, et al. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Cell. 1995;82:959
  27. Liu JY, Gromoll J, Cedars MI, et al. Identification of allelic variants in the follicle-stimulating hormone receptor genes of females with or without hypergonadotropic amenorrhea. Fertil Steril. 1998;70:326
  28. Whitney EA, Layman LC, Chan PJ, et al. The follicle-stimulating hormone receptor gene is polymorphic in premature ovarian failure and normal controls. Fertil Steril. 1995;64:518
  29. Conway GS, Conway E, Walker C, et al. Mutation screening and isoform prevalence of the follicle-stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome. Clin Endocrinol (Oxf). 1999;51:97
  30. Batista MC, Fonte Kohek MB, Frazzatto EST, et al. Mutation analysis of the follicle-stimulating hormone receptor gene in girls with gonadotropin-independent precocious puberty resulting from autonomous cystic ovaries. Fertil Steril. 2000;73:280
  31. Lyons J, Landis CA, Harsh G, et al. Two G protein oncogenes in endocrine tumors. Science. 1990;249:655
  32. Shen Y, Mamers P, Jobling T, et al. Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors. J Clin Endocrinol Metab. 1996;81:4159
  33. Hannon TS, Walker King D, Brinkman AD, et al. Premature thelarche and granulosa cell tumors: A search for FSH receptor and Gsα activating muations. J Pediatr Endocrinol Metab. 2000;15(suppl 3):891
  34. Taguchi O, Michael SD, Nishizuka Y. Rapid induction of ovarian granulosa cell tumors by 7,12-dimethylbenz (a) anthracene in neonatally estrogenized mice. Cancer Res. 1988;48:425
  35. Murphy ED, Beamer WG. Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the Wx/Wu genotype. Cancer Res. 1973;33:721
  36. Arisaka O, Matsumoto T, Hosaka A, et al. Cystic adult granulosa cell tumor causing precocious pseudopuberty in a six-year-old girl. Acta Pediatr. 1992;81:1061
  37. Cameron FJ, Scheimberg I, Stanhope R. Precocious pseudopuberty due to a granulosa cell tumour in seven-month-old female. Acta Pediatr. 1997;86:1016
  38. Pescovitz OH, Comite F, Hench K, et al. The NIH experience with precocious puberty: Diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analog therapy. J Pediatr. 1986;108:47

PII: S1083-3188(08)00293-3

doi: 10.1016/j.jpag.2008.10.003

Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 3 , Pages 173-179 , June 2009