Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 5 , Pages 318-322 , October 2009

The Prevalence of Abnormal Liver Enzymes and Metabolic Syndrome in Obese Adolescent Females with Polycystic Ovary Syndrome

  • Elaine Barfield, MD

      Affiliations

    • New York University School of Medicine, New York, New York
    • ,
  • Ying-Hua Liu, MD

      Affiliations

    • Department of Pediatrics, New York University School of Medicine, New York, New York
    • ,
  • Marion Kessler, MD

      Affiliations

    • Department of Pediatric Endocrinology, New York University School of Medicine, New York, New York
    • ,
  • Melissa Pawelczak, MD

      Affiliations

    • Department of Pediatric Endocrinology, New York University School of Medicine, New York, New York
    • ,
  • Raphael David, MD

      Affiliations

    • Department of Pediatric Endocrinology, New York University School of Medicine, New York, New York
    • ,
  • Bina Shah, MD

      Affiliations

    • Department of Pediatric Endocrinology, New York University School of Medicine, New York, New York
    • Corresponding Author InformationAddress correspondence to: Bina Shah, MD, Department of Pediatrics, New York University Medical Center, 550 First Avenue, New York, NY 10016

References 

  1. Setji TL, Holland ND, Sanders LL, et al. Nonalcoholic steatohepatitis and nonalcoholic fatty liver disease in young women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:1741
  2. Silfen ME, Denburg MR, Manibo M, et al. Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): Comparison between nonobese and obese adolescents. J Clin Endocrinol Metab. 2003;88:4682
  3. Coviello AD, Legro RS, Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab. 2006;91:492
  4. Michelmore KF, Balen AH, Dunger DB, Vessey MP, et al. Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol (Oxf). 1999;51:779
  5. Driscoll DA. Polycystic ovary syndrome in adolescence. Sem Reprod Med. 2003;21:301
  6. Lavine JE, Schwimmer JB. Nonalcoholic fatty liver disease in the pediatric population. Clin Liver Dis. 2004;8:549
  7. Kerkar N. Non-alcoholic steatohepatitis in children. Pediatr Transplant. 2004;8:613
  8. Tapia Ceballos L, Lopez Siguro JP, Jurado Ortiz A. Prevalence of metabolic syndrome and its components in obese children and adolescents. An Pediatr (Barc). 2007;64:352
  9. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 2004. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2003;81:19
  10. Weiss R, Dziura J, Burgert T, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362
  11. Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: A Working Group Report from the National High Blood Pressure Education Program. Pediatrics. 1996;98:649–658No. 4 October
  12. Cerda C, Perez-Ayus RM, Riquelme A. Nonalcoholic fatty liver disease in women with polycystic ovary syndrome. J Hepatol. 2007;47:412
  13. Tsilchorozidou T, Overton C, Conway GS. The pathophysiology of polycystic ovary syndrome. Clin Endocrinol. 2003;60:1
  14. Carmina E. Need for liver evaluation in polycystic ovary syndrome. J Hepatol. 2007;47:313
  15. Utzschneider KM, Kahn SE. The role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol. 2006;91:4753
  16. Fan JG, Zhu J, Li XJ, et al. Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol. 2005;20:1825

PII: S1083-3188(09)00160-0

doi: 10.1016/j.jpag.2009.03.003

Journal of Pediatric and Adolescent Gynecology
Volume 22, Issue 5 , Pages 318-322 , October 2009

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