Cultured Bilayered Skin Allograft for Vaginal Construction

published online 04 September 2009.

Abstract

Objective

This is the first report of live human cultured bilayered skin allograft (taken from another person) (LHCBSA) to line a dissected space to create a vagina.

Case

A 19-year-old with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) of vaginal and uterine agenesis had a space dissected and lined with LHCBSA. Although the lining devitalized within 2 weeks, there was a rapid ingrowth of vaginal mucosal cells from the vaginal dimple with an excellent long-term result.

Conclusion

This is the first report that LHCBSA is able to stimulate vaginal mucosal cell growth for a neovagina. It is possible that it might stimulate other surface tissue lining to cover adjacent raw areas such as bladder or esophagus.

Key Words: living cultured bilayered skin allograft, MRKH syndrome

1 Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine and Hospital, New York, NY

2 Department of Surgery, Mount Sinai Hospital (now Department of Surgery, University of Washington), New York, NY

3 Department of Pathology, Mount Sinai School of Medicine and Hospital, New York, NY

4 Department of Surgery, Mount Sinai Hospital (now Department of Surgery, N.Y.U. School of Medicine) New York, NY

Address correspondence to: Albert Altchek, MD, 1 East 89th St, New York, NY 10128

Harold Brem, MD had been a consultant for Organogenesis, Inc.

PII: S1083-3188(09)00249-6

doi:10.1016/j.jpag.2009.07.001

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