Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 1 , Pages e5-e8 , February 2010

Cultured Bilayered Skin Allograft for Vaginal Construction

  • Albert Altchek, MD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine and Hospital, New York, NY
    • Corresponding Author InformationAddress correspondence to: Albert Altchek, MD, 1 East 89th St, New York, NY 10128
    • ,
  • Andrew Hanflik, MD

      Affiliations

    • Department of Surgery, Mount Sinai Hospital (now Department of Surgery, University of Washington), New York, NY
    • ,
  • Liane Deligdisch, MD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine and Hospital, New York, NY
    • Department of Pathology, Mount Sinai School of Medicine and Hospital, New York, NY
    • ,
  • Harold Brem, MD

      Affiliations

    • Department of Surgery, Mount Sinai Hospital (now Department of Surgery, N.Y.U. School of Medicine) New York, NY

References 

  1. Altchek A. Congenital absence of the uterus and vagina. In:  Altchek A,  Deligdisch L editor. The Uterus, Pathology, Diagnosis and Management. New York (NY): Springer-Verlag; 1991;p. 272–293
  2. ACOG Committee Opinion No. 355. Vaginal agenesis: diagnosis, management and routine care. Obstet Gynecol. 2006;108:1605–1609
  3. Altchek A. Congenital anomalies – Rokitansky syndrome. In:  Altchek A,  Deligdisch L editor. Pediatric, Adolescent and Young Adult Gynecology. Oxford: Wiley-Blackwell; 2009;p. 215–230
  4. Frank RT. The formation of an artificial vagina without operation. Am J Obstet Gynecol. 1938;35:1053–1055
  5. Dinh TL, Veves A. The efficacy of Apligraf® in the treatment of diabetic foot ulcers. Plast Reconstr Surg. 2006;117(Suppl):152S–157S
  6. Karr J. Utilization of living bilayered cell therapy (Apligraf®) for heel ulcers. Adv Skin Wound Care. 2008;21:270–274
  7. Griffiths M, Ojeh N, Livingstone R, Price R, Navsaria H. Survival of Apligraf® in acute human wounds. Tissue Eng. 2004;10:1180–1185
  8. Phillips TJ, Manzoor J, Rojas A, et al. The longevity of a bilayered skin substitute after application to venous ulcers. Arch Dermatol. 2002;138:1079–1081
  9. Hu S, Kirsner RS, Falanga V, et al. Evaluation of Apligraf® persistence and basement membrane restoration in donor site wounds: a pilot study. Wound Repair Regen. 2006;14:427–433
  10. Drosou A, Kirsner RS, Kato T, et al. Use of a bioengineered skin equivalent for the management of difficult skin defects after pediatric multivisceral transplantation. J Am Acad Dermatol. 2005;52:854–858
  11. Wong T, McGrath JA, Navsaria H. The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol. 2007;156:1149–1155
  12. Allen JP. The Art of Medicine in Ancient Egypt. The Metropolitan Museum of Art. New York City. New Haven: Yale University Press; 2005;pp 70-73, object number 60
  13. Akopian G, Nunnery S, Piangenti J, et al. Outcomes of conventional wound treatment in a comprehensive wound center. Am Surg. 2006;72:314–317
  14. Fivenson D, Schershun L, Choucair M, et al. Graftskin® therapy in epidermolysis bullosa. J Am Acad Dermatol. 2003;48:886–892
  15. McGuire MK, Gessner S, Scheyer ET, et al. A pilot study to evaluate a tissue engineered bi-layered cell therapy as an alternative to tissue from the palate. J Periodontol. 2008;0:1–14
  16. Brucker SY, Gegusch M, Zubke W, et al. Neovagina creation in vaginal agenesis: development of a new laparoscopic Vecchietti-based procedure and optimized instruments in a prospective comparative interventional study in 101 patients. Fertil Steril. 2008;90:1940–1952

 Harold Brem, MD had been a consultant for Organogenesis, Inc.

PII: S1083-3188(09)00249-6

doi: 10.1016/j.jpag.2009.07.001

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 1 , Pages e5-e8 , February 2010

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