Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 2 , Pages 107-110 , April 2010

Ovarian Tissue Autologous Transplantation to the Upper Extremity for Girls Receiving Abdominal/Pelvic Radiation: 20-year Follow-up of Reproductive Endocrine Function

  • Marc R. Laufer, MD

      Affiliations

    • Division of Gynecology, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts, USA
    • Corresponding Author InformationAddress correspondence to: Marc R. Laufer, MD, Division of Gynecology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115; Phone: (617) 355-5785; Fax: (617) 730-0186
    • ,
  • Joseph Upton, MD

      Affiliations

    • Department of Surgery, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • ,
  • Samuel R. Schuster, MD

      Affiliations

    • Department of Surgery, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • ,
  • Holcombe Grier, MD

      Affiliations

    • Division of Hematology/Oncology, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • Division of Pediatric Oncology, Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • ,
  • S. Jean Emans, MD

      Affiliations

    • Division of Adolescent/Young Adult Medicine, Children's Hospital Boston; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • ,
  • Lisa Diller, MD

      Affiliations

    • Division of Hematology/Oncology, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts
    • Division of Pediatric Oncology, Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts

References 

  1. Wells SA, Ellis GJ, Gunnells JC, et al. Parathyroid autotransplantation in primary parathyroid hyperplasia. N Engl J Med. 1976;295:57–62
  2. Oktay K, Economos K, Kan M, et al. Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA. 2001;286:1490–1493
  3. Oktay K, Buyuk E, Rosenwaks Z, et al. A technique for transplantation of ovarian cortical strips to the forearm. Fertil Steril. 2003;80:193–198
  4. Radford JA, Lieberman BA, Brison DR, et al. Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin's lymphoma. Lancet. 2001;357:1172–1175

 The work described in this article was done at Children's Hospital Boston, Massachusetts. The authors declare no financial support. The results from this study were presented at the North American Society of Pediatric and Adolescent Gynecology, Miami, Florida, 2002.

 Capsule: The first cases of ovarian autotransplantation to the upper extremity for girls receiving abdominal pelvic radiation therapy resulted in long-term sex steroid production for spontaneous puberty, menarche, follicular development, and menses.

PII: S1083-3188(09)00306-4

doi: 10.1016/j.jpag.2009.09.005

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 2 , Pages 107-110 , April 2010

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