Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 3 , Pages 158-161 , June 2010

Insulin Resistance and Adolescent Girls with Polycystic Ovary Syndrome

  • S.M. Bhattacharya, MD

      Affiliations

    • S.C. Das Memorial Medical & Research Center and Vivekananda Institute of Medical Sciences, Kolkata, India
    • Corresponding Author InformationAddress correspondence to: Prof. S.M. Bhattacharya, Flat-4. Mohona, 5, New Raipur, Kolkata-700084, India
    • ,
  • M. Ghosh, MD, MBBS

      Affiliations

    • Department of Pharmacology, R.G. Kar Medical College, Kolkata, India

References 

  1. American Diabetes Association. Consensus Development Conference on Insulin Resistance. Diabetes Care. 1998;21:310
  2. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214
  3. Legro RS, Finegood D, Dunaif A. A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1999;83:2694
  4. Legro RS. Detection of insulin resistance and its treatment in adolescents with polycystic ovary syndrome. J Pediatr Endocrinol Metab. 2002;15(Suppl 5):1367
  5. Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;9:41
  6. Legro RS, Kunselman AR, Dodson WC, et al. Prevalence and predictors of risk for Type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective controlled study in 254 affected women. J Clin Endocrinol Metab. 1999;84:165
  7. Lewis V. Polycystic ovary syndrome: a diagnostic challenge. Obstet Gynecol Clin N Am. 2003;14:197
  8. Homburg R, Lambalk BC. Polycystic ovary syndrome in adolescence–a therapeutic conundrum. Hum Reprod. 2004;19:1039
  9. Gennarelli G, Holte J, Berglund L, et al. Prediction model for insulin resistance in the polycystic ovary syndrome. Hum Reprod. 2000;15:1098
  10. Morin-Papunen LC, Vauhkomen I, Koivunen RM, et al. Insulin sensitivity, insulin secretion and metabolic and hormonal parameters in healthy women and women with polycystic ovary syndrome. Hum Reprod. 2000;15:1266
  11. Holte J. Polycystic ovary syndrome and insulin resistance: thrifty genes struggling with over-feeding and sedentary life style?. J Endocrinol Invest. 1998;21:589
  12. Vrbiková J, Bendlová B, Hill M, et al. Insulin sensitivity and beta cell function in women with polycystic ovary syndrome. Diabetes Care. 2002;25:1217
  13. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997;18:774
  14. Nesto R. C-reactive protein, its role in inflammation, Type 2 diabetes and cardiovascular disease, and the effects of insulin-sensitizing treatment with thiazolidinediones. Diabet Med. 2004;21:810
  15. Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in the pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab. 2004;89:163
  16. Hsueh WA, Lyon CJ, Quiñones MJ. Insulin resistance and the endothelium. Am J Med. 2004;117:109
  17. Masuzaki H, Flier JS. Tissue-specific glucocorticoid reactivating enzyme, 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)–a promising drug target for the treatment of metabolic syndrome. Curr Drug Targets Immune Endocr Metab Disord. 2003;3:255
  18. Stuart CA, Gilkison CR, Smith MM, et al. Acanthosis nigricans as a risk factor for non-insulin dependent diabetes mellitus. Clin Paediatr. 1998;37:13
  19. Jeffrey Chang R, Coffler MS. Polycystic ovary syndrome: early detection in the adolescent. Clin Obstet Gynecol. 2007;50:178
  20. Fernandes AR, Japur de Sá Rosa e Silva AC, Romäo GS, et al. Insulin resistance in adolescents with menstrual irregularities. J Pediatr Adolesc Gynecol. 2005;18:269
  21. Pugeat M, Cousin P, Baret C, et al. Sex hormone-binding globulin during puberty in normal and hyperandrogenic girls. J Pediatr Endocrinol Metab. 2000;13:1277
  22. Driscoll DA. Polycystic ovary syndrome in adolescence. Semin Reprod Med. 2003;21:301

PII: S1083-3188(09)00347-7

doi: 10.1016/j.jpag.2009.10.004

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 3 , Pages 158-161 , June 2010

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