Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages 263-266, October 2010

Primary Ovarian Neuroblastoma

  • Joël Muhlstein, MD

      Affiliations

    • Pôle de Gynécologie-Obstétrique et Reproduction, Maternité Régionale Universitaire, de Nancy, Nancy, France
    • Corresponding Author InformationAddress correspondence to: Joël Muhlstein, MD, Pôle de Gynécologie-Obstétrique et Reproduction, Maternité Régionale Universitaire, 10, rue du Dr. Heydenreich, 54042 Nancy Cedex, France
  • ,
  • Sandra Rodriguez-Dahlhoff, MD

      Affiliations

    • Pôle de Gynécologie-Obstétrique et Reproduction, Maternité Régionale Universitaire, de Nancy, Nancy, France
  • ,
  • Béatrice Marie, MD

      Affiliations

    • Service d'Anatomie et de Cytologie Pathologiques, Hôpital Central, Centre Hospitalier Universitaire de Nancy, Nancy, France
  • ,
  • Fanny Fouyssac, MD

      Affiliations

    • Service d'Hémato-oncologie Pédiatrique et Transplantations Médullaires, Centre Hospitalier Universitaire de Nancy, Hôpital Brabois Enfants, Vandœuvre-lès-Nancy, France

published online 05 April 2010.

Abstract 

Background

The diagnosis of neuroblastoma is rare after the age of 15 years, and anatomical locations are essentially the adrenal glands and paraspinal sites. Neuroblastomas in adolescents are most often metastatic and carry a very poor prognosis.

Case Report

We report the case of a 17-year-old young woman in whom the diagnosis of primary ovarian neuroblastoma associated with a mature teratoma was established. A workup to assess disease extension was negative. Due to the localized characteristic of this tumor and the absence of N-myc oncogene amplification, and in spite of the unfavorable characteristic of the patient's age, treatment consisted of surgical removal of the tumor followed by clinical, laboratory and radiographic monitoring. No relapse has occurred during the 3-year follow up.

Conclusion

The issues raised by this rare case are discussed concomitantly with a review of the literature.

Key Words: Neuroblastoma, Ovary, Adolescent

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PII: S1083-3188(10)00007-0

doi:10.1016/j.jpag.2010.01.005

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages 263-266, October 2010