Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages e141-e144, October 2010

Anti-NMDA-Receptor Encephalitis: An Adolescent with an Ovarian Teratoma

  • Tammy S. Sonn, MD

      Affiliations

    • Division of General Obstetrics & Gynecology, Washington University School of Medicine, St. Louis Children's Hospital, Barnes Jewish Hospital, St. Louis, Missouri, USA
    • Corresponding Author InformationAddress correspondence to: Tammy S. Sonn, MD, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St. Louis, MO 63110
    • ,
  • Diane F. Merritt, MD

      Affiliations

    • Division of Pediatrics & Adolescent Gynecology, Department of Obstetrics and Gynecology, Washington University School of  Medicine, St. Louis Children's Hospital, Barnes Jewish Hospital, St. Louis, Missouri, USA

published online 07 June 2010.

Abstract 

Background

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has been reported to be associated with ovarian teratomas. In many patients, surgical excision has resulted in improvement.

Case

A previously healthy 14-year-old girl presented with confusion which later evolved into a comatose state. Imaging revealed an adnexal mass which was surgically removed and confirmed to be a mature teratoma. Her cerebral spinal fluid was positive for antibodies to NR1/NR2 heteromers of NMDA receptors.

Comments

Cystic teratomas are one of the most common benign ovarian lesions in children and young women. While an association of ovarian teratomas and paraneoplastic encephalitis is published in the neurologic literature, this association needs to be clarified for the practicing gynecologist who may be asked to consult on these patients.

Key Words: ovarian teratoma, encephalitis, paraneoplastic, adolescent, NMDA

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PII: S1083-3188(10)00107-5

doi:10.1016/j.jpag.2010.02.007

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages e141-e144, October 2010

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