Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages 285-289, October 2010

Characteristics of Polycystic Ovarian Syndrome and Relationship with Ghrelin in Adolescents

  • I.T. Ozgen, MD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Endocrinology, Ondokuz Mayis University Medical Faculty, Samsun, Turkey
    • Corresponding Author InformationAddress correspondence to: Ilker Tolga Ozgen, MD, Bakirkoy Maternity and Children Diseases Training and Research Hospital, Yenimahalle, Bakirkoy, Istanbul, Turkiye
    • ,
  • M. Aydin, MD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Endocrinology, Ondokuz Mayis University Medical Faculty, Samsun, Turkey
    • ,
  • A. Guven, MD

      Affiliations

    • Department of Pediatrics, Division of Pediatric Endocrinology, Ondokuz Mayis University Medical Faculty, Samsun, Turkey
    • ,
  • Y. Aliyazıcıoglu, MD

      Affiliations

    • Department of Clinical Biochemistry, Ondokuz Mayis University Medical Faculty, Samsun, Turkey

published online 31 May 2010.

Abstract 

Objective

Some points of pathogenesis in polycystic ovarian syndrome (PCOS) are still unknown. In this study we evaluated the characteristics of this disease and its relationship with ghrelin in adolescence.

Design

A prospective case control study was designed. Four groups: obese PCOS (n = 13), lean PCOS (n = 13), obese control (n = 10) and lean control (n = 10) were formed. Oral glucose tolerance tests (OGTT) were performed on all subjects. Laboratory and clinical features of groups were compared.

Setting

University pediatric endocrinology clinic.

Participants

Adolescents with PCOS.

Interventions

None.

Main Outcome Measures

Insulin resistance, ghrelin, delta ghrelin (difference of ghrelin between basal and 120th minute after OGTT), androgens

Results

Insulin resistance ratios were 93.3%, 46.6%, 50% in obese PCOS, lean PCOS and obese controls respectively. Ghrelin levels were lower in obese PCOS group but statistically different only between obese and lean PCOS groups. Ghrelin was correlated negatively with HOMA-IR (P < 0.001), 17 OH progesterone (P = 0.05), total (P = 0.015) and free testosterone (P = 0.013). Ghrelin suppression was blunted in PCOS groups. Ghrelin suppression ratios after glucose load were 24.4%, 28.7%, 36%, 35% obese PCOS, lean PCOS, obese control and lean control groups respectively.

Conclusion

Low ghrelin levels in obese PCOS patients, correlations between insulin resistance, androgens and ghrelin, blunted suppression of ghrelin after glucose load in PCOS have been considered as evidences of ghrelin role in pathogenesis of this syndrome.

Key Words: Polycystic ovarian syndrome, Adolescence, Insulin resistance, Ghrelin

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PII: S1083-3188(10)00111-7

doi:10.1016/j.jpag.2010.02.011

Journal of Pediatric and Adolescent Gynecology
Volume 23, Issue 5 , Pages 285-289, October 2010

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