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Review Article| Volume 1, ISSUE 4, P221-229, 1988

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Applications of hormone receptors in obstetrics and gynecology

  • Deborah A. Metzger
    Affiliations
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut
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  • Claude L. Hughes
    Correspondence
    Address reprint requests to: Claude L. Hughes, Ph.D., M.D., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
    Affiliations
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
    Search for articles by this author
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      Abstract

      Actions of all hormones are predominantly mediated by specific receptors. Progress in understanding the basic mechanisms of hormone-receptor interactions has led to several clinical applications of this receptor technology. Current applications include diagnosis and management of neoplasms of hormone-responsive tissues in the woman, diagnosis of previously inexplicable endocrine disorders, and development of new hormonal therapeutic agents. Our future diagnostic and therapeutic repertoire should continue to expand as these new molecular biology techniques mature.

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      References

        • Norman AW
        • Litwack G
        General considerations of hormones.
        in: Hormones. Academic Press, New York1987: 1-48
        • Tepperman J
        • Tepperman HM
        Overview of hormonal mechanisms, metabolic and endocrine physiology. Year Book Medical Publishers Inc., Chicago1987: 3-16
        • Sporn MB
        • Roberts AB
        Peptide growth factors are multifunctional.
        Nature. 1988; 332: 217
        • Rao CV
        Cell membrane receptors.
        in: Sciarra JJ Gynecology and Obstetrics. vol 5. Lippincott, Philadelphia1988: 1-12
        • Tepperman J
        • Tepperman HM
        Intracellular messenger systems involved in peptide hormone action: Cyclic AMP, calcium and phosphatidyl inositol metabolites, metabolic and endocrine physiology. Year Book Medical Publishers Inc., Chicago1987: 29-42
        • Clark JH
        • Markaverich BM
        Actions of ovarian steroid hormones.
        in: Knobil E Neill JD The Physiology of Reproduction. Raven Press, New York1988: 675
        • Yamamoto KR
        Steroid receptor regulated transcription of specific genes and gene networks.
        Ann Rev Genet. 1985; 19: 209
        • Duax WL
        • Griffin JF
        • Weeks CM
        Models for steroid-receptor interactions derived from x-ray crystallograph investigations.
        in: Sluyser M Interaction of Steroid Hormone Receptors with DNA. Ellis Horwood Ltd, England1985: 83
        • Milewich L
        Basis for hormonal therapy in breast and gynecological neoplasms.
        Postgrad Obstet Gynecol. 1984; 4: 1
        • McCarty KS
        • Miller LS
        • Cox EB
        • et al.
        Estrogen receptor analyses: Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies.
        Arch Pathol Lab Med. 1985; 109: 716
        • Horowitz KB
        • Sedlacek SM
        • d’Arville C
        • et al.
        Moudgil VK Progestin treatment, progesterone receptors and breast cancer, molecular mechanisms of steroid hormones. Walter de Gruyter, New York1985: 659-700
        • Bronzert DA
        • Davidson N
        • Lippman M
        Chrousos GP Loriaux DL Lipsett MB Estrogen and antiestrogen resistance in human breast cancer cell lines, steroid hormone resistance. Plenum, New York1986: 329-345
        • Christensen C
        • McCarty Jr, KS
        • Flowers J
        • et al.
        Analysis of estrogen receptor in ovarian carcinoma using biochemical and monoclonal antibody assays.
        Obstet Gynecol. 1988; (in press)
        • Schwartz PE
        • MacLusky N
        • Merino MJ
        • et al.
        Are cytosol estrogen and progestin receptors of prognostic significance in the management of epithelial ovarian cancers?.
        Obstet Gynecol. 1986; 68: 751
        • Blecher M
        • Bar RS
        Blecher M Bar RS Introduction to receptors, receptors and human disease. Williams and Wilkins, Baltimore1981: 2-23
        • Harrison LC
        • Heyma P
        Davies TF The receptor antibody diseases, autoimmune endocrine disease. John Wiley and Sons, New York1983: 101-125
        • Chiauzzi V
        • Cigorraga S
        • Escobar ME
        • et al.
        Inhibition of follicle-stimulating hormone receptor binding by circulating immunoglobulins.
        J Clin Endocrinol Metab. 1982; 54: 1221
        • Haas GG
        Davies TF Immunology of infertility, autoimmune endocrine disease. John Wiley and Sons, New York1983: 207-223
        • Liao S
        • Witte D
        • Murty CVR
        • et al.
        Roy AK Clark JH Antibodies to estrogen, progesterone, glucocorticoid, Vitamin D receptors and autoantibodies to androgen receptor, gene regulation by steroid hormones III. Springer-Verlag, New York1987: 137-154
        • Brown TR
        • Migeon CJ
        Chrouses GP Loriaux DL Lipsett MD Androgen receptors in normal and abnormal male sexual differentiation, steroid hormone resistance. Plenum, New York1986: 227-254
        • Keller DW
        • Wiest WG
        • Askin FB
        • et al.
        Pseudocorpus luteum insufficiency: A local defect of progesterone action on endometrial stroma.
        J Clin Endocrinol Metab. 1979; 48: 127
        • Cooke ID
        • Lambadarios C
        The endometrium.
        Clin Obstet Gynecol. 1974; 1: 369
        • Mortel R
        • Nantias WA
        Endocrine treatment of endometrial malignancy 1983–1984.
        in: Krieger DT Bardin CW Current Therapy in Endocrinology 1983—1984. BC Dekker, Inc, Philadelphia1983: 341
        • Speisberg TC
        • Boyd-Leinen PA
        Identification of biologically active and inactive steroid receptors.
        Clin Biochem. 1980; 5: 198
        • Raynaud JP
        • Fortin M
        • Hunt P
        • et al.
        Approaches to drug development using receptors.
        in: Gotto Jr, AM O’Malley BW The Role of Receptors in Biology and Medicine. Raven Press, New York1986: 63-77
        • Rifka SM
        • Pita Jr, JC
        • Loriaux DL
        Mechanism of interaction of digitalis with estradiol binding sites in rat uteri.
        Endocrinology. 1976; 99: 1091
        • Sauer MA
        • Rifka SM
        • Hawks RL
        • et al.
        Marijuana Interaction with the estrogen receptor.
        J Pharm Exp Ther. 1983; 224: 404
        • Verdeal K
        • Brown RR
        • Richardson T
        • et al.
        Affinity of phytoestrogens for estradiol binding proteins and effect of coumestrol on growth of 7,12-dimethylbenz [a] anthracene-induced rat mammary tumors.
        J Natl Cane Inst. 1980; 64: 285
        • Korach KS
        • McLachlin JA
        The role of the estrogen receptor in diethylstilbestrol toxicity.
        Arch Toxicol. 1985; 8: 33