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Abstract
Hypothalamic-pituitary disorders, either congenital or acquired, frequently affect
the growth and pubertal development of children. Two distinct groups were investigated.
The first group consisted of 70 patients with congenital optic nerve hypoplasia (ONH):
16 (73%) of the 22 patients had growth hormone deficiency; among the 21 patients who
were old enough and had adequate data for pubertal evaluation, 2 (10%) had delayed
or absent puberty and 4 (19%) had precocious puberty. In the second group, 14 children
had undergone head irradiation and/or surgery for brain/orbital tumors. Of these,
21% had precocious puberty, 36% had delayed puberty, and 10 (90%) of 11 patients tested
had growth hormone deficiency. The pubertal growth spurt can conceal hGH deficiency.
Linear growth continues at a rate near normal for childhood but low for puberty. Careful
monitoring of growth and early initiation of growth hormone replacement are essential
to achieve a normal adult height in adolescents with hypothalamic-pituitary disease.
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References
- Hinz R Rosenfeld R Delayed puberty, growth abnormalities. 1st ed. Churchill Livingstone, New York1987: 141-165
- Growth and growth hormone: Disorders of the Anterior Pituitary. Clinical Pediatric and Adolescent Endocrinology. 1st ed. Saunders, Philadelphia1982: 1-48
- Boyd Suzanne Puberty in the male and female. Reproductive Endocrinology. 2nd ed. Saunders, Philadelphia1986: 313-384
- Hormonal, metabolic and neurologic abnormalities associated with septo-optic dysplasia.Acta Endocrinol. 1984; 107: 282
- Sexual precocity in association with septo-optic dysplasia and hypothalamic hypopituitarism.J Pediatr. 1978; 92: 748
- Endocrine sequelae of antineoplastic therapy in childhood head and neck malignancies.J Clin Endocrinol Metab. 1980; 50: 329
- Endocrine function, morbidity, and mortality after surgery for craniopharyngioma.Arch Dis Child. 1982; 57: 837
- Growth and endocrine function after treatment for medulloblastoma.Arch Dis Child. 1983; 58: 772
- Primary gonadal damage following treatment of brain tumors in childhood.J Pediatr. 1983; 103: 562
- Long-term effects of treatment on endocrine function in children with brain tumors.Ann Neurol. 1983; 14: 528
- Long-term effects of cranial irradiation on endocrine function in children with brain tumors.Cancer. 1985; 56: 2189
- Hypopituitarism after external irradiation.Ann Intern Med. 1975; 83: 771
- Assessment of hypothalamic-pituitary function in women after external head irradiation.J Clin Endocrinol Metab. 1979; 49: 623
- Effect of hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors.J Clin Endocrinol Metab. 1982; 54: 1164
- Physical growth.Am J Clin Nutr. 1979; 32: 607
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© 1988 Springer-Verlag New York Inc. Published by Elsevier Inc. All rights reserved.
