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Abstract
We describe the presentation, clinical evaluation, and outcome of 3 cases of hyperprolactinemia
in adolescent females. Case #1 is a 16 and 4/12-year-old female with secondary amenorrhea.
Pregnancy testing had previously been negative with no further evaluation. Bilateral
expressible galactorrhea was discovered on physical examination and a serum prolactin
was 110.3 ng/ml. The computed tomography (CT) scan was normal and menses resumed with
bromocriptine therapy. Case #2 is a 15 and Vi2-year-old female who came for a routine
yearly examination. She had no complaint and was menstruating regularly. Specific
questioning revealed a history of galactorrhea confirmed by physical examination.
A serum prolactin was 47.0 ng/ml. A CT scan showed a pituitary microadenoma. She was
treated with bromocriptine. Case #3 is a 16 and 9/12-year-old female who was seen
for primary amenorrhea. An evaluation revealed a serum prolactin of 143.0 ng/ml. A
CT scan showed a pituitary microadenoma. She was treated with bromocriptine and began
to menstruate regularly. For the physician seeing the adolescent female, thorough
medical histories must include questions regarding the breast, and evaluation for
galactorrhea must be part of every breast examination. The physician also needs to
be familiar with the evaluation of amenorrhea and/or galactorrhea and include determination
of serum prolactin when indicated. We recommend obtaining a constant enhanced CT scan
or magnetic resonance imaging (MRI) of the sella turcica to evaluate any elevation
of serum prolactin.
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References
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Article info
Footnotes
†This paper was presented in part at the Second Annual Meeting of the North American Society for Pediatric and Adolescent Gynecology held in Cleveland, OH September 1987.
Identification
Copyright
© 1988 Springer-Verlag New York Inc. Published by Elsevier Inc. All rights reserved.
