This paper is only available as a PDF. To read, Please Download here.
We describe the presentation, clinical evaluation, and outcome of 3 cases of hyperprolactinemia in adolescent females. Case #1 is a 16 and 4/12-year-old female with secondary amenorrhea. Pregnancy testing had previously been negative with no further evaluation. Bilateral expressible galactorrhea was discovered on physical examination and a serum prolactin was 110.3 ng/ml. The computed tomography (CT) scan was normal and menses resumed with bromocriptine therapy. Case #2 is a 15 and Vi2-year-old female who came for a routine yearly examination. She had no complaint and was menstruating regularly. Specific questioning revealed a history of galactorrhea confirmed by physical examination. A serum prolactin was 47.0 ng/ml. A CT scan showed a pituitary microadenoma. She was treated with bromocriptine. Case #3 is a 16 and 9/12-year-old female who was seen for primary amenorrhea. An evaluation revealed a serum prolactin of 143.0 ng/ml. A CT scan showed a pituitary microadenoma. She was treated with bromocriptine and began to menstruate regularly. For the physician seeing the adolescent female, thorough medical histories must include questions regarding the breast, and evaluation for galactorrhea must be part of every breast examination. The physician also needs to be familiar with the evaluation of amenorrhea and/or galactorrhea and include determination of serum prolactin when indicated. We recommend obtaining a constant enhanced CT scan or magnetic resonance imaging (MRI) of the sella turcica to evaluate any elevation of serum prolactin.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Pediatric and Adolescent Gynecology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Diagnosis and management of prolactinomas.Fertil Steril. 1985; 43: 5
- Changes in computed tomographic findings in microprolactinomas before and after bromocriptine.Acta Endocrinol. 1985; 110: 308
- Bromocriptine treatment of microprolactinomas. Evidence of stable prolactin decrease after drug withdrawal.J Clin Endocrinol Metab. 1985; 60: 764
- Pituitary adenomas in childhood.Acta Endocrinol (suppl). 1986; 279: 434
- John Wiley & Sons, New York1978: 18-19 Adolescent Medicine in Primary Care.
- Hyperprolactinemia causing primary amenorrhea.J Pediatr. 1981; 99: 802
- Bromocriptine treatment of seven women with primary amenorrhea and prolactin-secreting pituitary tumours.Clin Endocrinol. 1979; 10: 145
- Williams and Wilkins, Baltimore1983: 142 Clinical Gynecologic Endocrinology and Infertility. Third Edition.
- Hyperprolactinemia and delayed puberty. A report of three cases and their response to therapy.Pediatrics. 1983; 71: 572
- Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series.N Eng J Med. 1981; 304: 156
- Longitudinal evaluation of patients with untreated prolactin-secreting pituitary adenomas.Am J Obstet Gynecol. 1981; 139: 835
- The natural history of idiopathic hyperprolactinemia.J Clin Endocrinol Metab. 1985; 60: 855
- Mishell D Davajan V Infertility, Contraception, and Reproductive Endocrinology. Second Edition. Medical Economics Books, New Jersey1986: 295
- Report of the national symposium on the clinical management of prolactin-related reproductive disorders.Fertil Steril. 1986; 45: 607
- Hyperprolactinemia and associated pituitary prolactinomas.Obstet Gynecol. 1985; 65: 661
- The inability of dynamic tests of prolactin and TSH secretion to differentiate between tumorous and non-tumorous hyperprolactinemia.J Endocrinol Invest. 1985; 8: 49
- Hyperprolactinemia long-term effects of bromocriptine.Am J Med. 1983; 75: 868
- Pituitary adenomas in patients under 20 years old. A clinicopathological study of 12 cases.J Neuro-Oncol. 1986; 4: 79
†This paper was presented in part at the Second Annual Meeting of the North American Society for Pediatric and Adolescent Gynecology held in Cleveland, OH September 1987.
© 1988 Springer-Verlag New York Inc. Published by Elsevier Inc. All rights reserved.