Research Article| Volume 1, ISSUE 3, P177-180, 1988

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Genital lichen sclerosus in prepubertal girls

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      Thirty-five girls with a diagnosis of genital lichen sclerosus were seen in review. Follow-up ranged from 1 to 11 1/2 years with almost half of the patients followed for 5 or more years. Only 5 of 27 girls examined did not have clinical evidence of genital lichen sclerosus lesions. Of these 5, 2 girls were still intermittently symptomatic, and another 2 had been followed for only 1 year. When the patient's symptomatology alone was considered, 9 had unchanged symptoms and 26 had improvement or resolution of their symptoms. Eleven of the 26 had improvement, 12 had total resolution of symptoms, and 3 had always been asymptomatic. No relationship between menarche and symptomatic improvement or resolution of the disease was observed. Of the 22 girls with lichen sclerosus lesions, 3 had atrophy of the labia minora and clitoral phimosis, and 1 also had marked contracture of the introitus. This review challenges the commonly held view that prepubertal genital lichen sclerosus is a process that resolves with time and the advent of puberty or estrogenization. The current philosophy of withholding topical testosterone, a potentially curative therapy, from all premenarchal girls should be reevaluated in selected cases.

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        • Clark JA
        • Muller SA
        Lichen sclerosus et atrophicus in children: A report of 24 cases.
        Arch Dermatol. 1967; 95: 476
        • Wallace HJ
        Lichen sclerosus et atrophicus.
        Trans St. Johns Derm Soc. 1971; 57: 9
        • Torek E
        • Orley J
        • Goracz G
        • et al.
        Lichen sclerosus et atrophicus in children.
        Mod Probl Paediatr. 1975; 17: 262
        • Chernosky ME
        • Derbes VJ
        • Burks JW
        Lichen sclerosus et atrophicus in children.
        Arch Dermatol. 1957; 75: 647
        • Barker LP
        • Gross P
        Lichen sclerosus et atrophicus of the female genitalia: A clinical study and diagnostic guide.
        Arch Dermatol. 1962; 85: 362
        • Ditkowsky SP
        • Falk AB
        • Baker N
        • et al.
        Lichen sclerosus et atrophicus in childhood.
        Amer J Dis Child. 1956; 91: 52
        • Post CF
        Lichen sclerosus et atrophicus.
        Arch Dermatol. 1958; 77: 763
        • Muramatsu T
        • Kitamura W
        • Sakamoto K
        Lichen sclerosus et atrophicus in children.
        J Dermatol. 1985; 12: 377
        • Barclay DL
        • Macey HB
        • Reed RJ
        Lichen sclerosus et atrophicus of the vulva in children.
        Obstet Gynecol. 1966; 27: 637
        • Kindler T
        Lichen sclerosus et atrophicus in young subjects.
        Brit J Dermatol. 1953; 65: 269
        • Lascano EF
        • Leopoldo FM
        • Mazzini MA
        Lichen sclerosus et atrophicus in childhood: Report of 6 cases.
        Obstet Gynecol. 1964; 89: 619
        • Zakon SJ
        In response.
        Arch Dermatol. 1964; 24: 872
        • Chetty GN
        • Kamalam A
        • Janaki VR
        • et al.
        Lichen sclerosus et atrophicus of the vulva (case reports).
        Indian J Pediatr. 1980; 17: 699
        • Dogliotti M
        • Bentley-Phillips CB
        • Schmaman A
        Lichen sclerosus et atrophicus in the Bantu.
        Brit J Dermatol. 1974; 89: 619
        • Scully JP
        Lichen sclerosus et atrophicus.
        Arch Dermatol. 1958; 77: 763
        • Gross P
        Generalized lichen sclerosus et atrophicus associated with band-like scleroderma (Koebner phenomenon and lichen sclerosus).
        Arch Dermatol. 1958; 77: 752
        • Aaronson LD
        • Baler GR
        • Schiff BL
        Lichen sclerosus et atrophicus occurring in childhood.
        Arch Dermatol. 1962; 85: 746
        • Flynt J
        • Gallup DG
        Childhood lichen sclerosus.
        Obstet Gynecol. 1979; 53: 795
        • Friedrich EG
        • MacLaren NK
        Genetic aspects of vulvar lichen sclerosus.
        Am J Obstet Gynecol. 1984; 150: 161
        • Laude TA
        • Narayanaswamy G
        • Rajkumar S
        Lichen sclerosus et atrophicus in an eleven-year-old girl: Report of a case.
        Cutis. 1980; 26: 78
        • Lawrence WD
        Lichen sclerosus et atrophicus of the vulva: Report of a case.
        Obstet Gynecol. 1959; 14: 65
        • Meyrick-Thomas RM
        • Kennedy CTC
        The development of lichen sclerosus et atrophicus in monozygotic twin girls.
        Brit J Dermatol. 1986; 114: 377
        • Friedrich EG
        Lichen sclerosus.
        J Reprod Med. 1976; 17: 147
        • Friedrich EG
        Topical testosterone for benign vulvar dystrophy.
        Obstet Gynecol. 1971; 37: 677
        • Williams GA
        • Richardson AC
        • Hathcock EW
        Topical testosterone in dystrophic diseases of the vulva.
        Am J Obstet Gynecol. 1966; 96: 21
        • Zelle K
        Treatment of vulvar dystrophies with topical testosterone propionate.
        Am J Obstet Gynecol. 1971; 109: 570