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Abstract
Primary dysmenorrhea represents an extremely common cause of school and work absence
as well as general disability for adolescent and young women. Improved understanding
of the biochemical and mechanical changes responsible for primary dysmenorrhea make
specific therapy directed at the underlying cause possible. Therapy with nonsteroidal
antiinflammatory agents can provide relief in 60−95+ % of patients. Objective studies
of uterine activity indicate that these agents act to suppress the uterine activity
associated with dysmenorrhea pain. By understanding the therapies available it is
now possible to talk of effective pain prevention for these patients. The adolescent
with dysmenorrhea need no longer be disabled by menstrual pain.
Key Words
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References
- An epidemiologic study of young women with dysmenorrhea.Am J Obstet Gynecol. 1982; 144: 655
- The incidence of primary dysmenorrhea in teenagers.Arch Gynecol. 1981; 230: 173
- Mish FC Webster's Ninth New Collegiate Dictionary. Merriam-Webster, Inc., Springfield, Massachusetts1986
- Beiträge zur physiologischen geburtskunde.Arch Gynakol. 1872; 3: 58
- Beiträge zur physiologischen geburtskunde.Arch Gynakol. 1872; 4: 34
- Beiträge zur physiologischen geburtskunde.Arch Gynakol. 1872; 4: 193
- Beiträge zur physiologischen geburtskunde.Arch Gynakol. 1872; 4: 418
- Contractions of a non-pregnant multiparous human uterus.Am J Obstet Gynecol. 1925; 9: 255
- The cause of primary dysmenorrhea.JAMA. 1932; 99: 1466
- The effect of the ovarian hormones on the human (nonpuerperal) uterus.Am J Obstet Gynecol. 1937; 34: 379
- Electrical and mechanical activity of the human non-pregnant uterus.Am J Obstet Gynecol. 1939; 38: 1008
- Activity of the human non-pregnant uterus.Am J Physiol. 1940; 53: 407
- Studies on the motility of the human uterus in vivo.Endocrinology. 1938; 23: 79
- Uterine contractility in functional dysmenorrhea.Endocrinology. 1940; 27: 23
- L’Activité électrique de l’uterus dans la dysmenorrhee functionnelle.Gynecol et Obstet. 1948; 47: 850
- Myometrial physiology and its relation to pelvic pain.JAMA. 1947; 134: 1081
- Inherent motility patterns and response characteristics on the nonpregnant human uterus.Am J Obstet Gynecol. 1966; 96: 824
- Dysmenorrhea and its therapy: A uterine contractility study.Am J Obstet Gynecol. 1970; 106: 104
- A phyto-pharmacological study of menstrual toxin.J Pharmacol Exp Ther. 1924; 22: 413
- Menstrual toxins.Wein Klin Wochenschr. 1920; 33: 356
- A plain muscle stimulant in the menstrual fluid.Nature. 1957; 180: 1198
- Plain-muscle stimulants in extracts of menstrual fluid and of endometrial curettings.J Physiol. 1958; 144: 68
- Some evidence that the endometrium produces a hormone that stimulates plain muscle.J Endocrinol. 1959; 18: 1
- Myometrial responses to the plain-muscle stimulant.J Endocrinol. 1959; 19: 150
- Further studies on the plain muscle stimulant present in human endometrium.J Endocrinol. 1960; 20: 6
- The separation of the smooth-muscle stimulants in menstrual fluid.J Physiol. 1961; 156: 225
- Some physiological properties of the 'menstrual stimulant' substances Al and A2.J Reprod Fertil. 1963; 6: 315
- The isolation and identification of two smooth muscle stimulants from menstrual fluid.Nature. 1963; 200: 960
- The isolation and identification of two smooth muscle stimulants from menstrual fluid.Nature. 1963; 200: 993
- Prostaglandins in endometrium and menstrual fluid from normal and dysmenorrheic subjects.J Obstet Gynaecol Br Comm. 1965; 72: 185
- Effect of intravenous administration of prostaglandin El and F2a on the contractility of the non-pregnant women uterus in vivo.Acta Obstet Gynecol Scand Suppl. 1970; 49: 19
- Prostaglandins in the human endometrium.Int J Fertil. 1967; 12: 335
- In vivo studies of the motility patterns of the non-pregnant human uterus. II The effect of oestrogen on myometrial activity.Acta Obstet Gynecol Scand. 1968; 47: 225
- In vivo studies of the motility pattern of the nonpregnant human uterus.Am J Obstet Gynecol. 1968; 101: 473
- The intranasal treatment of dysmenorrhea. With a report of ninety-three cases.JAMA. 1914; 62: 6
- Dysmenorrhea.Am J Obstet Gynecol. 1953; 65: 505
- La sympathectomie hypogastrique: A-t-elle sa place dans latherapeutique gynécologique?.Presse Med. 1925; 33: 98
- Use of presacral sympathectomy in the treatment of dysmenorrhea: A second look after twenty-five years.Am J Obstet Gynecol. 1964; 89: 16
- Relief of primary dysmenorrhea.Obstet Gynecol. 1960; 16: 730
- Pain and pain relief in essential dysmenorrhea.Am J Obstet Gynecol. 1951; 62: 559
- Dysmenorrhea. Treatment with Isoxsuprine.Obstet Gynecol. 1960; 15: 220
- Chlorpromazine and chlorpromazine combinations in the treatment of dysmenorrhea.Am J Obstet Gynecol. 1957; 74: 419
- The treatment of dysmenorrhea. With special reference to the primary type.Med Clin North Am. 1951; 35: 861
- Management of primary dysmenorrhea.Obstet Gynecol. 1962; 20: 66
- A comparative study of Ibuprofen and Paracetamol in primary dysmenorrhea.J Int Med Res. 1974; 2: 395
- A clinical trial of indomethacin and ibuprofen in dysmenorrhea.J Reprod Med. 1978; 21: 219
- Ibuprofen therapy for dysmenorrhea.J Reprod Med. 1978; 20: 246
- Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: Effect on prostaglandin levels in menstrual fluid.Am J Obstet Gynecol. 1979; 135: 102
- The treatment of dysmenorrhea with naproxen sodium.Am J Obstet Gynecol. 1977; 127: 818
- Treatment of primary dysmenorrhea with prostaglandin synthetase inhibitors—A promising therapeutic alternative.Acta Obstet Gynecol Scand. 1978; 57: 421
- Naproxen sodium in dysmenorrhea.Obstet Gynecol. 1978; 52: 583
- Pain relief with naproxen following insertion of an intrauterine device.J Reprod Med. 1974; 13: 226
- Naproxen sodium in uterine pain following intrauterine contraceptive device insertion.Am J Obstet Gynecol. 1979; 134: 575
- Antagonism by fena-mates of prostaglandin F2a and of slow reacting substance on human bronchial muscle.Nature. 1968; 219: 864
- Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.Nature New Biol. 1971; 231: 232
- Use of prostaglandin synthetase inhibitors in analyzing the role of prostaglandins in reproductive physiology.in: Robinson HJ Vane JR Prostaglandin Synthetase Inhibitors. Raven Press, New York1974: 271-287
- Multiple sites of interaction between prostaglandins and non-steroidal anti-inflammatory agents.Prostaglandins. 1975; 9: 349
- Ramwell PW Pharriss BB Aspirin and prostaglandins. Prostaglandins in Cellular Biology. Plenum Press, New York1972: 1-47
- New aspects of the mode of action of nonsteroidal anti-inflammatory drugs.Ann Rev Pharmacol. 1973; 14: 57
- Primary dysmenorrhea. Alleviation by an inhibitor of prostaglandin synthesis and action.Obstet Gynecol. 1974; 44: 709
- Trial of prostaglandin-synthetase inhibitors in primary dysmenorrhea.Lancet. 1978; 1: 345
- Flufenamic acid in treatment of primary spasmodic dysmenorrhea.Lancet. 1978; 1: 348
- Use of Mefenamic acid in the treatment of primary dysmenorrhea.JAMA. 1979; 241: 2713
- Mefenamic acid (Ponstel) for treating primary spasmodic dysmenorrhea.Curr Ther Res. 1981; 29: 544
- A double-blind comparison of a propionic acid derivative (Ibuprofen) and a fenamate (Mefenamic acid) in the treatment of dysmenorrhea.Obstet Gynecol. 1983; 61: 628
- Simultaneous objective and subjective evaluation of meclofenamate sodium in the treatment of primary dysmenorrhea.Am J Obstet Gynecol. 1987; 157: 611
- The dynamics of nonsteroidal anti-inflammatory therapy for primary dysmenorrhea.Obstet Gynecol. 1987; 70: 785
- Meclofenamate sodium is an inhibitor of both the 5-Lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade In Vitro.Prostaglandins, Leukotrienes Med. 1986; 23: 229
- Differential effects of anti-inflammatory drugs on lipoxygenase and cyclooxygenase activities of neutrophils from a reverse passive Arthus reaction.Biochem Biophys Res Commun. 1983; 112: 586
- Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRA-A antagonist, FPL 55712.Prostaglandins. 1983; 25: 1
- Prostaglandin synthetase inhibitors and dysmenorrhea.Acta Obstet Gynecol Scand Suppl. 1979; 87: 73
- Primary dysmenorrhea treatment with prostaglandin inhibitors: A review.Am J Obstet Gynecol. 1981; 140: 874
- Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea.Am J Obstet Gynecol. 1984; 148: 96
- Pharmacology of nonsteroidal anti-inflammatory drugs and their use in dysmenorrhea.in: Dawood MY McGuire JL Demers LM Premenstrual Syndrome and Dysmenorrhea. Urban & Schwarzenberg, Baltimore1984: 159-176
- Primary dysmenorrhea.US Pharm. 1984; 41
- The effect of naproxen sodium on the intrauterine pressure and menstrual pain of dysmenorrhea patients.Prostaglandins. 1977; 13: 193
- The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrhea patients.Prostaglandins. 1978; 15: 1055
- Anaprox in dysmenorrhea: Reduction of pain and intrauterine pressure.Am J Obstet Gynecol. 1979; 135: 455
- Endogenous prostaglandins in dysmenorrhea and the effect of prostaglandin synthetase inhibitors (PGSI) on uterine contractility.Acta Obstet Gynecol Scand Suppl. 1979; 87: 51
- Relief of menstrual discomfort and dysmenorrhea and simultaneous suppression of uterine activity by isoxepac.Acta Obstet Gynecol Scand. 1980; 59: 367
- Combined effects of diflunisal and nifedipine on uterine contractions in dysmenorrhea patients.Prostaglandins. 1982; 23: 237
- Intrauterine pressure changes during mefenamic acid treatment of primary spasmodic dysmenorrhea.Am J Obstet Gynecol. 1982; 143: 286
- Anti-prostaglandin therapy for primary spasmodic dysmenorrhea.Today's Ther Trends. 1983; 1: 17
- Naproxen and indomethacin in the treatment of primary dysmenorrhea.Acta Obstet Gynecol Scand Suppl. 1979; 87: 87
- The relief of primary dysmenorrhea by ketoprofen and indomethacin.Prostaglandins. 1979; 18: 647
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© 1988 Springer-Verlag New York Inc. Published by Elsevier Inc. All rights reserved.