Abstract
Objectives
Patients with diabetes mellitus (DM) are at risk for vulvovaginal candidasis. The
aim of this study was to determine the species-specific prevalence rate and risk of
candidiasis in patients with type 1 DM.
Methods
Children aged between 8-16 years were included in the study. Clinical and laboratory
features of diabetes and evidence of genital symptoms were recorded. Vaginal swabs
were taken from patients and placed on Sabouraud’s dextrose agar and incubated. Following
fasting overnight for 12 hours venous blood samples were taken simultaneously for
analyses of blood glucose, HbA1c, and lipid profile. A simple 1-time fluconazole treatment
regimen was used to treat patients with vulvo-vaginal candidiasis.
Results
Candida species were isolated in 30 of 76 (39%) swabs of patients with type 1 DM.
Subjects who had candida colonization and candidiasis were all acute. The predominant
candida species isolated from patients with type 1 DM were C.albicans 50%, C. glabrata
36.6%, C.crusei 3.3%, C.spesies 6.6%, and C.dubliniensis 3.3%. 42 patients had symptoms.The
prevalence of candidiasis in symptomatic patients was 59.2%. Subjects with vulvo-vaginal
candidiasis had higher mean HbA1c when compared to those who had no such infection
(P = .047).
Conclusions
There seems to be a significant link between hyperglycemia and vulvo-vaginal candidiasis
in patients with type 1 DM. Improving glucose control may reduce the risk of candidiasis
and potentially symptomatic infection among children with diabetes. Because of high
rate of colonization with candida species in diabetes, patients should undergo periodic
screening for genital candidiasis.
Key Words
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Article info
Publication history
Published online: April 01, 2013
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2013 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
