Abstract
Study Objective
To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB)
levels as markers for pubertal progression rate in girls with central precocious puberty
(CPP).
Design, Setting, Participants, Interventions, and Main Outcome Measures
A total of 148 girls were enrolled, including 65 girls with premature thelarche and
83 girls with CPP, grouped on the basis of the results of gonadotropin-releasing hormone
stimulation tests. Girls with CPP underwent a 6-month follow-up, and were further
divided into 2 subgroups: the progressive CPP (P-CPP) group (n = 55) and the slowly
P-CPP (SP-CPP) group (n = 28). Serum AMH and INHB levels were assessed in all enrolled
girls. Using receiver operating characteristic curves, we analyzed the diagnostic
performance of AMH and INHB to differentiate the 2 forms of CPP.
Results
Our data showed that AMH and INHB offer the potential to act as markers that distinguish
SP-CPP from P-CPP. Compared with the SP-CPP group, girls with P-CPP showed lower AMH
levels and higher INHB levels. On the basis of the receiver operating characteristics
analysis, the area under the curve was 0.92 for the combination of AMH and INHB, with
80% sensitivity and 89.3% specificity.
Conclusion
Our results suggest that serum AMH and INHB levels provide a promising method in differentiating
SP-CPP from P-CPP.
Key Words
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Article info
Publication history
Published online: February 01, 2017
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
