Abstract
Study Objective
The aim of this retrospective study was to evaluate endometriosis in adolescent and
young girls and further to review the menstrual, reproductive characteristics, and
risk factors.
Design and Setting
We reviewed the medical records of adolescent and young girls with endometriosis from
2 different countries. Data were collected and analyzed from charts of 900 patients
with endometriosis.
Participants and Interventions
Fifty-five female adolescents aged between 13 and 21 years (mean age 18.3 years) participated
in our series. This study was conducted in the Obstetric and Gynecology Department
of Venizeleio General Hospital of Crete and involved all patients diagnosed with endometriosis
between 1996 and 2016.
Main Outcome Measures
Statistical methods included χ2 and Mann-Whitney U test.
Results
Of 900 patients with endometriosis we found 55 female adolescents (6.1%). The mean
age was 18.3 ± 2.3 years, significantly younger compared with the advanced endometriosis
patients (32.7 ± 7.2; P < .001). Regarding the menstrual reproductive and others characteristics, we observed
several differences in adolescent young girls compared with the advanced age endometriosis
group. The factors associated with an increased risk for young women include age at
menarche, dysmenorrhea, history of asthma, and a positive family history of endometriosis.
Additionally, we report on 16 of 55 (32%) adolescent women with endometriosis and
congenital malformations (P < .01) and 5 patients who were diagnosed with dry eye syndrome.
Conclusion
There is an association between endometriosis in adolescent and young women and risk
factors including early menarche, early onset of dysmenorrhea, history of asthma,
previous surgical procedures, obstructive genital anomalies, and family history of
endometriosis.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric and Adolescent GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy.J Pediatr Adolesc Gynecol. 1997; 10: 199
- Origins and progression of adolescent endometriosis.Reprod Sci. 2016; 23: 1282
- Endometriosis in adolescence.in: Matalliotakis I. Arici A. New Developments in Endometriosis, 17. 2011: 394
- Endometriosis in association with uterine anomaly.Am J Obstet Gynecol. 1986; 154: 39
- Early-life factors and endometriosis risk.Fertil Steril. 2015; 104: 964
- CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.Fertil Steril. 2003; 79: 702
- Familial aggregation of endometriosis in the Yale Series.Arch Gynecol Obstet. 2008; 278: 507
- Diagnostic experience among 4,334 women reporting surgically diagnosed endometriosis.Fertil Steril. 2009; 91: 32
- Gynecologic pain: dysmenorrhea, acute and chronic pelvic pain, endometriosis, and premenstrual syndrome.in: Emans S.J. Laufer M.R. Pediatric & Adolescent Gynecology. 6th ed. Wolters Kluwer Lippincott Williams & Wilkins, Philadelphia2012: 238
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996.Fertil Steril. 1997; 67: 817
- Advanced stage endometriosis in adolescents and young women.J Pediatr Adolesc Gynecol. 2014; 27: 320
- Endometriosis in adolescents.JSLS. 2015; 19 (http://dx.doi.org/10.4293/JSLS.2015.00019)
- Prevalence of endometriosis among adolescent school girls with severe dysmenorrhea: a cross sectional prospective study.Int J Health Sci (Qassim). 2015; 9: 273
- Pain typology and incident endometriosis.Hum Reprod. 2015; 30: 2427
- Endometriosis in adolescence: practical rules for an earlier diagnosis.Pediatr Ann. 2016; 45: e332
- The epidemiology of endometriosis.Ann N Y Acad Sci. 2002; 955: 11
- Adolescent endometriosis: report of a series of 55 cases, with a focus on clinical presentation and long-term issues.J Minim Invasive Gynecol. 2015; 22: 834
- Septate uterus with cervical duplication and longitudinal vaginal septum: a report of five new cases.Fertil Steril. 2004; 81: 1133
- Etiologies of uterine malformations.Am J Med Genet A. 2016; 170: 2141
- Genome-wide association meta-analysis identifies new endometriosis risk loci.Nat Genet. 2012; 44: 1355
- Septate uterus with cervical duplication: a rare malformation.Fertil Steril. 1994; 62: 415
- Presumed nasolacrimal endometriosis.Ophthal Plast Reconstr Surg. 2008; 24: 47
- Nasolacrimal endometriosis. A case report.Ophthalmic Res. 2006; 38: 313
- Sex and sex steroid influences on the dry eye syndromes.in: Pflugfelder S.C. Beuerman R.W. Stern M.E. Dry Eye and Ocular Surface Disorders. Marcel Dekker, New York2004 (165)
Article Info
Publication History
Published online: May 27, 2017
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
