Case Report| Volume 31, ISSUE 3, P325-327, June 2018

Download started.


Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient

Published:October 26, 2017DOI:



      Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They are typically benign, however, malignant transformation rarely occurs. We report a low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient.


      The patient was a 12-year-old girl with an asymptomatic ovarian cyst and subsequent cystectomy. Final pathology identified a solid tumor with glial tissue within the cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma.

      Summary and Conclusion

      There are few data on astrocytomas in the gynecologic tract. Risk factors for malignant transformation in a mature cystic teratoma include increased age, postmenopausal status, elevated carcinoma antigen 125, and large tumor size. Interestingly, this patient had a history of partial trisomy 20, which has been associated with teratoma formation in a mouse model.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Pediatric and Adolescent Gynecology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Westhoff C.
        • Pike M.
        • Vessey M.
        Benign ovarian teratomas: a population-based case-control study.
        Br J Cancer. 1988; 58: 93
        • Comerci Jr., J.T.
        • Licciardi F.
        • Bergh P.A.
        • et al.
        Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature.
        Obstet Gynecol. 1994; 84: 22
        • Park J.Y.
        • Kim D.Y.
        • Kim J.H.
        • et al.
        Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution.
        Eur J Obstet Gynecol Reprod Biol. 2008; 141: 173
        • Ulker V.
        • Numanoglu C.
        • Akbayir O.
        • et al.
        Malignant transformation arising from mature cystic teratoma of the ovary: a report of six cases.
        J Obstet Gynaecol Res. 2012; 38: 849
        • Thaker S.
        Squamous cell carcinoma developing in mature cystic teratoma of the ovary: a rare case.
        J Obstet Gynaecol India. 2012; 62: 63
        • Berger N.
        • Pochaczevsky R.
        Astrocytoma-containing ovarian teratoma in childhood.
        Am J Roentgenol Radium Ther Nucl Med. 1969; 107: 647
        • Badran Y.R.
        • Obeidat F.N.
        • Freij M.A.
        Low-grade astrocytoma arising in a mature ovarian teratoma in an adolescent.
        Clin Ovarian Cancer Other Gynecol Malig. 2013; 6: 62
        • Park C.H.
        • Jung M.H.
        • Ji Y.I.
        Risk factors for malignant transformation of mature cystic teratoma.
        Obstet Gynecol Sci. 2015; 58: 475
        • Rim S.Y.
        • Kim S.M.
        • Choi H.S.
        Malignant transformation of ovarian mature cystic teratoma.
        Int J Gynecol Cancer. 2006; 16: 140
      1. Genetic and Rare Diseases Information Center (GARD): Chromosome 20 trisomy. Available at: Accessed October 9, 2016.

        • Prokhorova T.A.
        • Harkness L.M.
        • Frandsen U.
        • et al.
        Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel.
        Stem Cells Dev. 2009; 18: 47