Abstract
Background
Mature cystic teratomas are the most common ovarian neoplasm in adolescents. They
are typically benign, however, malignant transformation rarely occurs. We report a
low-grade astrocytoma arising from a mature cystic teratoma in an adolescent patient.
Case
The patient was a 12-year-old girl with an asymptomatic ovarian cyst and subsequent
cystectomy. Final pathology identified a solid tumor with glial tissue within the
cyst, reported as low-grade astrocytoma arising in a mature cystic teratoma.
Summary and Conclusion
There are few data on astrocytomas in the gynecologic tract. Risk factors for malignant
transformation in a mature cystic teratoma include increased age, postmenopausal status,
elevated carcinoma antigen 125, and large tumor size. Interestingly, this patient
had a history of partial trisomy 20, which has been associated with teratoma formation
in a mouse model.
Key Words
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Article info
Publication history
Published online: October 26, 2017
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
