Abstract
Study Objective
Nonepithelial malignant ovarian tumors are rare in the pediatric and adolescent population.
The aim of this study was to observe the spectrum of pathology, presentation, outcome,
and risk factors for survival of pediatric nonepithelial malignant ovarian tumors
in a Chinese pediatric population.
Design, Setting, Participants, Interventions, and Main Outcome Measures
This was a retrospective study of 171 girls (median age at presentation of 14 years)
diagnosed with primary malignant ovarian tumors between 1990 and 2014 at the Yat-Sen
Memorial Hospital and Cancer Center of Sun Yat-sen University. Symptoms, pathological
data, treatments, and outcomes were obtained retrospectively from the medical records.
Results
Most (85.96%, 147/171) tumors occurred in patients aged 10-18 years and most cases
were International Federation of Gynecology and Obstetrics stage I (68.42%, 117/171).
The predominant pathological type was germ cell tumors (87.13%, 149/171). All patients
underwent surgery, and 87 (50.88%, 87/171) underwent conservative incomplete staging
surgery (unilateral salpingo-oophorectomy or tumor excision). The 5-year progression-free
survival (PFS) was 59.2%. The 5-year overall survival (OS) was 88.7%. Surgical hospital
(hazard ratio, 0.388; 95% confidence interval, 0.213-0.706; P = .002) was independently associated with PFS. Recurrence state (hazard ratio, 163.26;
95% confidence interval, 1.321-20,181.875; P = .038) was independently associated with OS.
Conclusion
Ovarian cancers in children and adolescents have features of good prognosis. Girls
who received their first surgery in a tertiary hospital had better PFS. Patients who
did not suffer recurrence had better OS.
Key Words
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Article info
Publication history
Published online: October 06, 2017
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
