Abstract
Study Objective
This study was designed to evaluate and compare the serum total prostate-specific
antigen (PSA) levels in adolescent girls in with and without polycystic ovarian syndrome
(PCOS) to show whether evaluation of PSA levels have a diagnostic benefit over existing
diagnostic criteria.
Design
Case-control study.
Setting
A territory referral center.
Participants
A total of 89 (15-19 years) nonobese (body mass index, 18-24.9) adolescents with PCOS
(n = 42) and controls without PCOS (n = 47) were enrolled in the study.
Interventions
Pathophysiological features of PCOS and serum total PSA levels were determined at
the time of study enrollment.
Main Outcome Measures
Determination, comparison, and diagnostic performance of serum total PSA levels in
diagnosis of PCOS in adolescent girls were the main outcome measures of the study.
Results
The serum total PSA levels of adolescents with PCOS were detected to be higher than
for control participants (0.63 ± 1.38 ng/mL vs 0.48 ± 0.95 ng/mL) without meeting
statistical significance (P = .923). There was a correlation between total PSA levels and indices of insulin
resistance like the homeostasis insulin resistance model (r = 0.414; P = .010). The serum total PSA level was not a discriminative parameter for diagnosis
of PCOS in adolescent girls (area under the curve, 0.559; P = .476).
Conclusion
The serum total PSA level was not a predictor of PCOS in adolescent girls. This finding
might be related to the extemporal nature of tissues capable of PSA production and
lack of sufficient exposure interval to hyperandrogenemia, rather than lack of stimulatory
relationship between serum androgens.
Key Words
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Article info
Publication history
Published online: November 20, 2017
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
