Abstract
Study Objective
To review our local experience with urogenital rhabdomyosarcoma (RMS) to determine
the most common clinical presentation(s).
Design
Retrospective case series of all female patients with urogenital RMS who presented
to a tertiary pediatric hospital between 1996 and 2016. All institutional electronic
pathology reports were screened for RMS and those that were pelvic in origin and occurred
in female patients were included for further analysis. Seventeen cases of urogenital
RMS in female patients were identified and reviewed.
Setting
This study was conducted at The Royal Children's Hospital in Melbourne, Australia.
This is a tertiary referral center for the state of Victoria and surrounding areas,
which services more than 1.5 million pediatric patients.
Participants
Female pediatric patients (ages 0-18 years) who presented to The Royal Children's
Hospital with eventual pathologic tissue diagnosis of urogenital RMS.
Main Outcome Measures
The cases were reviewed for clinical presentation, duration of symptoms before initial
presentation, time to tissue diagnosis, and outcomes of treatment.
Results
Of the 17 cases reviewed, 5 (29%) presented with perineal mass, 4 (24%) presented
with each of abdominal mass and grape-like lesions/hemorrhagic mass at the introitus,
3 (18%) with nonspecific symptoms only, and 1 (6%) with vulvar inflammation.
Conclusion
The clinical presentation of urogenital RMS in women is heterogeneous, and the classically
described presentation of grape-like lesions at the introitus and vaginal bleeding
represents only a small proportion of clinical presentations. Awareness of other presentations,
which appear to be more common than previously recognized, needs to be increased to
ensure timely diagnosis and treatment.
Key Words
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Article info
Publication history
Published online: February 05, 2018
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
