Abstract
Study Objective
The goal of this study was to assess a group of women with Mayer–Rokitansky–Küster–Hauser
(MRKH) syndrome with surgically created neovaginas in the interest of uterus transplantation
(UTx) and to recruit the first group of applicants for a UTx trial.
Design and Setting
This was an original prospective study using semistructured interviews.
Participants
A study group of 50 women with MRKH syndrome with Vecchietti neovaginas was recruited
via letter of invitation.
Interventions and Main Outcome Measures
Interest of MRKH women in obtaining experimental UTx for the treatment of absolute
uterine factor infertility.
Results
A total of 50 women responded via e-mail and 31 (62% [31 of 50] of the study group)
expressed serious interest in UTx after complete information about its risks and benefits
was provided during the first semistructured interview. They subsequently agreed to
participate in additional interviews and further examinations. Because of various
reasons, only 9 women were prepared to enter our UTx trial (18% [9 of 50] of the study
group). Three recipients/donors were accepted into the living donor arm and 6 into
the deceased brain donor arm of the trial.
Conclusion
Nearly two-thirds of our MRKH syndrome study group women with surgically created neovaginas
were interested in UTx and motivated to undergo this method of absolute uterine factor
infertility treatment. Therefore, this group of women might be approached to participate
in ongoing and future UTx trials. Future studies of women with MRKH syndrome might
confirm or disprove the results of our survey.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Pediatric and Adolescent GynecologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- First clinical uterus transplantation trial: a six-month report.Fertil Steril. 2014; 101: 1228
- Uterus transplantation trial: 1-year outcome.Fertil Steril. 2015; 103: 199
- Livebirth after uterus transplantation.Lancet. 2015; 385: 607
- Human uterus transplantation in focus.Br Med Bull. 2016; 117: 69
- Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal.Hum Reprod Update. 2008; 14: 415
- Müllerian agenesis: etiology, diagnosis, and management.Obstet Gynecol Surv. 2000; 55: 644
- The clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging.Hum Reprod. 2006; 21: 792
- Mayer-Rokitansky-Küster-Hauser syndrome.Orphanet J Rare Dis. 2007; 2: 13
- Mayer-Rokitansky-Küster-Hauser syndrome: a review of 245 consecutive cases managed by multidisciplinary approach with vaginal dilators.Fertil Steril. 2012; 97: 686
- Neovagina creation in vaginal agenesis: development of a new laparoscopic Vecchietti-based procedure and optimized instruments in a prospective comparative interventional study in 101 patients.Fertil Steril. 1940; 2008: 90
- Should uterus transplants be publicly funded?.J Med Ethics. 2016; 42: 559
- Surrogate in vitro fertilization outcome in typical and atypical forms of Mayer-Rokitansky-Küster-Hauser syndrome.Hum Reprod. 2012; 27: 126
- Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic train: outcomes of surrogate pregnancies.Fertil Steril. 1997; 67: 387
- Ethical considerations in the era of the uterine transplant: an update of the Montreal Criteria for the Ethical Feasibility of uterine transplantation.Fertil Steril. 2013; 100: 924
- Transplantation of the human uterus.Int J Gynaecol Obstet. 2002; 76: 245
- Preliminary results of the first human uterus transplantation from multiorgan donor.Fertil Steril. 2013; 99: 470
- Risks for donors in uterus transplantation.Reprod Sci. 2013; 20: 1406
- Deceased donor uterine transplantation. Innovation and adaptation.Obstet Gynecol. 2016; 128: 837
- Uterus transplantation in France: for which patients?.Eur J Obstet Gynecol Reprod Biol. 2016; 205: 7
- Sexual function in women treated with dilators for vaginal agenesis.J Pediatr Adolesc Gynecol. 2005; 18: 39
Article info
Publication history
Published online: May 08, 2018
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
