The goal of this study was to assess a group of women with Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome with surgically created neovaginas in the interest of uterus transplantation (UTx) and to recruit the first group of applicants for a UTx trial.
Design and Setting
This was an original prospective study using semistructured interviews.
A study group of 50 women with MRKH syndrome with Vecchietti neovaginas was recruited via letter of invitation.
Interventions and Main Outcome Measures
Interest of MRKH women in obtaining experimental UTx for the treatment of absolute uterine factor infertility.
A total of 50 women responded via e-mail and 31 (62% [31 of 50] of the study group) expressed serious interest in UTx after complete information about its risks and benefits was provided during the first semistructured interview. They subsequently agreed to participate in additional interviews and further examinations. Because of various reasons, only 9 women were prepared to enter our UTx trial (18% [9 of 50] of the study group). Three recipients/donors were accepted into the living donor arm and 6 into the deceased brain donor arm of the trial.
Nearly two-thirds of our MRKH syndrome study group women with surgically created neovaginas were interested in UTx and motivated to undergo this method of absolute uterine factor infertility treatment. Therefore, this group of women might be approached to participate in ongoing and future UTx trials. Future studies of women with MRKH syndrome might confirm or disprove the results of our survey.
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- First clinical uterus transplantation trial: a six-month report.Fertil Steril. 2014; 101: 1228
- Uterus transplantation trial: 1-year outcome.Fertil Steril. 2015; 103: 199
- Livebirth after uterus transplantation.Lancet. 2015; 385: 607
- Human uterus transplantation in focus.Br Med Bull. 2016; 117: 69
- Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal.Hum Reprod Update. 2008; 14: 415
- Müllerian agenesis: etiology, diagnosis, and management.Obstet Gynecol Surv. 2000; 55: 644
- The clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging.Hum Reprod. 2006; 21: 792
- Mayer-Rokitansky-Küster-Hauser syndrome.Orphanet J Rare Dis. 2007; 2: 13
- Mayer-Rokitansky-Küster-Hauser syndrome: a review of 245 consecutive cases managed by multidisciplinary approach with vaginal dilators.Fertil Steril. 2012; 97: 686
- Neovagina creation in vaginal agenesis: development of a new laparoscopic Vecchietti-based procedure and optimized instruments in a prospective comparative interventional study in 101 patients.Fertil Steril. 1940; 2008: 90
- Should uterus transplants be publicly funded?.J Med Ethics. 2016; 42: 559
- Surrogate in vitro fertilization outcome in typical and atypical forms of Mayer-Rokitansky-Küster-Hauser syndrome.Hum Reprod. 2012; 27: 126
- Congenital absence of the uterus and vagina is not commonly transmitted as a dominant genetic train: outcomes of surrogate pregnancies.Fertil Steril. 1997; 67: 387
- Ethical considerations in the era of the uterine transplant: an update of the Montreal Criteria for the Ethical Feasibility of uterine transplantation.Fertil Steril. 2013; 100: 924
- Transplantation of the human uterus.Int J Gynaecol Obstet. 2002; 76: 245
- Preliminary results of the first human uterus transplantation from multiorgan donor.Fertil Steril. 2013; 99: 470
- Risks for donors in uterus transplantation.Reprod Sci. 2013; 20: 1406
- Deceased donor uterine transplantation. Innovation and adaptation.Obstet Gynecol. 2016; 128: 837
- Uterus transplantation in France: for which patients?.Eur J Obstet Gynecol Reprod Biol. 2016; 205: 7
- Sexual function in women treated with dilators for vaginal agenesis.J Pediatr Adolesc Gynecol. 2005; 18: 39
Published online: May 08, 2018
The authors indicate no conflicts of interest.
© 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.