Abstract
Study Objective
Our goal was to describe the period prevalence of venous thromboembolism (VTE) and
characterize adolescent female patients diagnosed with VTE by describing their age,
race, and number of comorbidities. Female adolescents with estrogen exposure were
of particular interest because estrogen-containing contraceptives increase the risk
of VTE.
Design, Setting, Participants, and Interventions
We queried the Pediatric Health Information System database for International Classification
of Diseases, Ninth/Tenth Revision, Clinical Modification codes to identify female
patients aged 12-18 years diagnosed with a VTE or pulmonary embolism from April 2006
to March 2016 in the United States. Patient demographic characteristics and comorbidities
were also analyzed. We divided our study population into two five-year groups and
calculated the change in period prevalence of VTE between those groups.
Main Outcome Measures
Primary diagnosis of VTE in the extremities, or pulmonary embolism.
Results
The period prevalence of VTE increased from 2.3 female adolescents per 10,000 hospitalized
children (group 1) to 3.3 per 10,000 (group 2), representing a statistically significant
increase of 0.010% (P < .001). Caucasian and black individuals were most commonly affected. The number
of girls affected increased steadily from ages 12 to 16 years and a large percentage
(59.6%) had four or more comorbidities. In patients (n = 32) with estrogen exposure,
more than 96% had one or more comorbidity in addition to estrogen exposure.
Conclusion
Pediatric health care providers should be aware that the period prevalence of VTEs
in female adolescents is increasing. Those with a history of estrogen exposure rarely
develop VTEs from estrogen alone and they typically have multiple comorbidities.
Key Words
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Article info
Publication history
Published online: June 19, 2018
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
