Abstract
Study Objective
To compare ovarian function between adolescents conceived using assisted reproductive
technology (AcART) and adolescents who were conceived spontaneously (AcSP).
Design
Multicenter study of ovarian function in AcART because of male or tubal infertility.
Setting
University Hospital.
Participants
We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. The participants were
born at term (≥37 weeks of gestation) with normal birth weights (≥2500 g) from singleton
pregnancies.
Interventions
None.
Main Outcome Measures
Differences in ovulation, reproductive hormones, and ovarian morphology.
Results
AcART had an older age of menarche than that of AcSP, even after adjusting for maternal
age at menarche, gestational age, and birth weight (P = .027). AcART had lower incidence of ovulation (P = .021) and higher luteinizing hormone serum levels (P = .01) than those of AcSP. The incidence of oligomenorrhea and the cycle length were
similar between AcART and AcSP. AcART had levels of anti-Müllerian hormone, inhibin
B, follicle-stimulating hormone, estradiol, and androgens similar to those of AcSP.
The ovarian morphology, ovarian volume, and follicle counts were similar in both groups.
Conclusion
AcART had later menarche, lower ovulation rates, and higher luteinizing hormone levels
than those of AcSP. Future studies should investigate whether these findings are indicative
of a risk of ovarian dysfunction later in life for AcART.
Key Words
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Article info
Publication history
Published online: November 28, 2018
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
