Case Report| Volume 32, ISSUE 3, P330-333, June 2019

Virilization in a Girl Caused by an Ovarian Yolk Sac Tumor: A Case Report

  • Min Yang
    Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
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  • Ying Xin
    Address correspondence to: Ying Xin, PhD, Department of Pediatrics, Shengjing Hospital, China Medical University, No 36 Sanhao Street, Heping District, Shenyang, 110004 Liaoning, P.R. China; Phone: (86) 18940251876
    Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
    Search for articles by this author
Published:January 07, 2019DOI:



      Yolk sac tumors (YSTs) are rare malignancies that originate from germ cells and rarely present with endocrine symptoms. We report a case of a 13-year-old girl with a YST manifesting as virilization.


      A 13-year-old girl was diagnosed with a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified using hematoxylin and eosin staining and immunohistochemistry.

      Summary and Conclusion

      This case suggests that clinicians should consider the possibility of YST when encountering patients with symptoms of virilization. When a YST is found to have endocrine function, a functioning stroma could present. Immunohistochemistry is useful for identifying stromal cells and performing a differential diagnosis.

      Key Words

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