Yolk sac tumors (YSTs) are rare malignancies that originate from germ cells and rarely present with endocrine symptoms. We report a case of a 13-year-old girl with a YST manifesting as virilization.
A 13-year-old girl was diagnosed with a YST with endocrine symptoms because of Leydig cells in the stroma, which were identified using hematoxylin and eosin staining and immunohistochemistry.
Summary and Conclusion
This case suggests that clinicians should consider the possibility of YST when encountering patients with symptoms of virilization. When a YST is found to have endocrine function, a functioning stroma could present. Immunohistochemistry is useful for identifying stromal cells and performing a differential diagnosis.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Pediatric and Adolescent Gynecology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Ovarian tumors secreting androgens: an infrequent cause of hyperandrogenism.Minerva Ginecol. 2019; 71: 72
- Sclerosing stromal tumour of the ovary in a postmenopausal woman presenting with virilization.J Exp Ther Oncol. 2016; 11: 213
- Endodermal sinus tumor of the ovary with virilization.Am J Surg Pathol. 1981; 5: 385
- Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation): a light microscopic, ultrastructural and immunohistochemical study of seven cases.Cancer. 1981; 50: 2355
- Ovarian yolk sac tumor with virilization during pregnancy: immunohistochemical demonstration of Leydig cells as functioning stroma.Pathol Int. 2000; 50: 520
- Cutologic features of functioning stromal cells in a yolk sac tumor of the the ovary. A case report.Acta Cytol. 2004; 48: 83
- Microcystic Leydig cell tumors mimicking yolk sac tumor: a report of four cases.Am J Surg Pathol. 1999; 23: 546
- Precocious puberty secondary to a mixed germ cell-sex cord-stromal tumor associated with an ovarian yolk sac tumor: a case report.J Med Case Rep. 2012; 26: 162
Published online: January 07, 2019
The authors indicate no conflicts of interest.
© 2019 Published by Elsevier Inc. on behalf of North American Society for Pediatric and Adolescent Gynecology.