Stevens-Johnson Syndrome (SJS) is a rare spectrum of delayed hypersensitivity reactions
most commonly occurring after exposure to antibiotics and anti-epileptics. Mucous
membranes are commonly involved, including the vulvovaginal mucosa. No standardized
treatment exists but mainstays include supportive therapy and Intravenous Immunoglobulin
(IVIG) therapy with or without steroids. Sequelae of vulvovaginal involvement in SJS
may result in atrophy, stenosis, synechiae, and dyspareunia.
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