Stevens-Johnson Syndrome (SJS) is a rare spectrum of delayed hypersensitivity reactions most commonly occurring after exposure to antibiotics and anti-epileptics. Mucous membranes are commonly involved, including the vulvovaginal mucosa. No standardized treatment exists but mainstays include supportive therapy and Intravenous Immunoglobulin (IVIG) therapy with or without steroids. Sequelae of vulvovaginal involvement in SJS may result in atrophy, stenosis, synechiae, and dyspareunia.
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