Idiopathic nephrotic syndrome is a glomerular disease characterized by proteinuria which leads to hypoalbuminemia and peripheral edema. Dependent edema is a common sequela of the protein-deficient state, often starting as periorbital edema and migrating to the lower extremities and sacral region. In boys with protein-wasting disorders, this may result in scrotal edema. Less frequently described in the literature is edema in the female homologue, the labia majora. We present a case of unusually severe dependent labial edema in a prepubertal girl with idiopathic nephrotic syndrome.
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