Increasing numbers of transmasculine (TM) youth (transgender and gender diverse (TGD)
youth assigned female at birth) are avoiding puberty with endogenous hormones and
utilizing GnRH analogs followed by masculinizing gender affirming hormone therapy
(GAHT). Clinicians providing early hormone care must monitor development, including
growth. Growth spurts and final adult height are determined by numerous factors including
parental heights, timing of puberty, and hormonal factors. We have noted anecdotally
that a high percentage of TM youth attain their adult heights early. Few studies have
systematically assessed growth variations in TGD youth, and little is known about
the effects of therapies on height outcomes. The goal of this study is to assess growth
patterns in TM youth before and after GnRH analog therapy and various types of GAHT.
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