Abstract
Irregular menstrual cycles due to anovulation are well described in the first few
years after menarche, but the normal developmental trajectory from anovulatory to
mature ovulatory cycles during adolescence remains undefined. In this article we review
the very limited understanding of this final stage of female reproductive axis development
and discuss why additional research in this area is critical to the health of women.
Key Words
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References
- Variation of the human menstrual cycle through reproductive life.Int J Fertil. 1967; 12: 77
- The prognosis for adolescents with menstrual abnormalities.Am J Obstet Gynecol. 1966; 94: 637
- Adolescent menstrual characteristics as predictors of gynaecological health.Ann Hum Biol. 1983; 10: 31
- World Health Organization multicenter study on menstrual and ovulatory patterns in adolescent girls. II. Longitudinal study of menstrual patterns in the early postmenarcheal period, duration of bleeding episodes and menstrual cycles. World Health Organization Task Force on Adolescent Reproductive Health.J Adolesc Health Care. 1986; 7: 236
- Serum steroids and pituitary hormones in female puberty: a partly longitudinal study.Clin Endocrinol (Oxf). 1980; 12: 107
- Ovarian function after the menarche and hormonal contraception.Int J Gynaecol Obstet. 1988; 27: 249
- The incidence of anovular cycles in women.J Reprod Fertil. 1969; : 77
- Menstrual patterns in adolescent Swiss girls: a longitudinal study.Ann Hum Biol. 1984; 11: 495
- Rapid maturation of the reproductive axis during perimenarche independent of body composition.J Clin Endocrinol Metab. 2000; 85: 1021
- Maturation of the hypothalamo-pituitary-ovarian axis in adolescent girls.J Clin Endocrinol Metab. 1982; 54: 241
- Incidence of ovulation in the years after the menarche.J Endocrinol. 1983; 97: 213
- The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls.J Endocrinol. 1984; 102: 265
- The menstrual cycle.Major Probl Obstet Gynecol. 1977; 7: 1
- Daily levels of salivary progesterone during menstrual cycle in adolescent girls.Fertil Steril. 1992; 58: 685
- Hormone rhythms and breast cancer chronoepidemiology: salivary progesterone concentrations in pre- and post-menarchal girls and in normal premenopausal women.Chronobiol Int. 1984; 1: 159
- The development of cyclic pituitary-gonadal function in adolescent females.J Clin Endocrinol Metab. 1973; 37: 714
- Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles.J Clin Endocrinol Metab. 1983; 57: 82
- Regular menstrual cycles and premenstrual molimina as indicators of ovulation.Obstet Gynecol. 1979; 53: 411
- Serum pregnenolone, progesterone, 17-hydroxyprogesterone, testosterone and 5 alpha-dihydrotestosterone during female puberty.J Clin Endocrinol Metab. 1977; 45: 1039
- Ovulation and menstrual function of adolescent girls with central precocious puberty after therapy with gonadotropin-releasing hormone agonists.J Clin Endocrinol Metab. 1992; 75: 890
- Basal body temperature assessment: is it useful to couples seeking pregnancy?.MCN Am J Matern Child Nurs. 2005; 30 ([quiz: 7]): 290
- Basal body temperature: unreliable method of ovulation detection.Fertil Steril. 1981; 36: 729
- Hormones in saliva.Crit Rev Clin Lab Sci. 1986; 23: 95
- Healthy post-menarchal adolescent girls demonstrate multi-level reproductive axis immaturity.J Clin Endocrinol Metab. 2019; 104: 613
- Endocrine characteristics of adolescent menstrual cycles: impact of early menarche.J Steroid Biochem. 1984; 20: 231
- Puberty in girls: correlation of serum levels of gonadotropins, prolactin, androgens, estrogens, and progestins with physical changes.J Clin Endocrinol Metab. 1976; 43: 775
- Menstrual patterns in the first gynecological year: a systematic review.J Pediatr Adolesc Gynecol. 2018; 31: 557
- Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty.Horm Res Paediatr. 2012; 77: 137
- Onset of ovulation after menarche in girls: a longitudinal study.J Clin Endocrinol Metab. 2008; 93: 1186
- Pituitary responsiveness to LHRH and TRH in adolescent girls.Bull Schweiz Akad Med Wiss. 1978; 34: 241
- Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities.Fertil Steril. 1987; 48: 78
- Pituitary control of ovarian function--concepts derived from gonadotrophin therapy.Aust N Z J Obstet Gynaecol. 1978; 18: 46
- Review article: the polycystic ovary syndrome.Clin Endocrinol (Oxf). 1980; 12: 177
- The diagnosis of polycystic ovary syndrome in adolescents.Am J Obstet Gynecol. 2010; 203: 201
- The diagnosis of polycystic ovary syndrome during adolescence.Horm Res Paediatr. 2015; 83: 376
- Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo-amenorrhoea at age 18 years.Hum Reprod. 2004; 19: 383
- Irregular menstruation and hyperandrogenaemia in adolescence are associated with polycystic ovary syndrome and infertility in later life: Northern Finland Birth Cohort 1986 study.Hum Reprod. 2014; 29: 2339
- Menstrual disorders in a paediatric and adolescent gynaecology clinic: patient presentations and longitudinal outcomes.Hong Kong Med J. 2011; 17: 391
- Endocrine determinants of fertility: serum androgen concentrations during follow-up of adolescents into the third decade of life.J Clin Endocrinol Metab. 1990; 71: 970
- Longitudinal evaluation of the different gonadotropin pulsatile patterns in anovulatory cycles of young girls.J Clin Endocrinol Metab. 1992; 74: 836
- Longitudinal change of sonographic ovarian aspects and endocrine parameters in irregular cycles of adolescence.Pediatr Res. 1995; 38: 974
- Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome.N Engl J Med. 1989; 320: 559
- Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.J Clin Endocrinol Metab. 1994; 79: 1158
- Accelerated 24-hour luteinizing hormone pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of polycystic ovarian syndrome.J Clin Endocrinol Metab. 1994; 79: 119
- The diagnosis of polycystic ovary syndrome in adolescents.Pediatrics. 2015; 136: 1154
- Diagnosis of the polycystic ovary syndrome in adolescence: comparison of adolescent and adult hyperandrogenism.J Pediatr Endocrinol Metab. 2000; 13: 1285
- Chronic gynecological conditions reported by US women: findings from the National Health Interview Survey, 1984 to 1992.Am J Public Health. 1996; 86: 195
- International patterns and trends in endometrial cancer incidence, 1978-2013.J Natl Cancer Inst. 2018; 110: 354
- Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood.J Clin Endocrinol Metab. 2015; 100: 1537
- The Global strategy for women’s, children’s and adolescents’ health (2016-2030): a roadmap based on evidence and country experience.Bull World Health Organ. 2016; 94: 398
Article info
Publication history
Published online: February 14, 2019
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
Published by Elsevier Inc. on behalf of North American Society for Pediatric and Adolescent Gynecology.