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Development of Ovulatory Menstrual Cycles in Adolescent Girls

  • Lauren J. Carlson
    Affiliations
    Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
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  • Natalie D. Shaw
    Correspondence
    Address correspondence to: Natalie D. Shaw, MD, MMSc, Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Dr, MD A2-03, Research Triangle Park, NC 27709; Phone (984) 287-3716; fax: (301) 451-5539
    Affiliations
    Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Search for articles by this author
Published:February 14, 2019DOI:https://doi.org/10.1016/j.jpag.2019.02.119

      Abstract

      Irregular menstrual cycles due to anovulation are well described in the first few years after menarche, but the normal developmental trajectory from anovulatory to mature ovulatory cycles during adolescence remains undefined. In this article we review the very limited understanding of this final stage of female reproductive axis development and discuss why additional research in this area is critical to the health of women.

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