Abstract
Background
Turner syndrome is a genetic disorder resulting from the absence of or structural
abnormality of one X chromosome. The presence of Y chromosome material in girls with
Turner syndrome confers an increased risk of benign and malignant germ cell tumor
and prophylactic bilateral gonadectomy is recommended.
Case
A 10-year-old Turner mosaic syndrome (45X/46XY) patient underwent prophylactic gonadectomy
after unremarkable preoperative pelvic imaging. Histopathology showed a streak right
gonad, and left gonad with gonadoblastoma with limited degree of infiltrating germinoma.
Summaryand Conclusion
Gonadoblastoma and dysgerminoma have been reported in girls with Turner mosaic who
carry Y chromosome material. Prophylactic gonadectomy should be considered in these
girls without delay.
Key Words
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References
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Article info
Publication history
Published online: July 04, 2019
Footnotes
Julie L. Strickland, MD, MPH is a Nexplanon instructor and receives an honorarium from Merck. The remaining authors indicate no conflicts of interest.
The findings of this study were presented, in part, at the 29th Annual Clinical and Research Meeting of the North American Society for Pediatric and Adolescent Gynecology, Chicago, Illinois, in April 2015.
Identification
Copyright
© 2019 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
