The purpose of this prospective study was to assess the effectiveness of norethisterone (NET) in the management of abnormal uterine bleeding (AUB) in adolescents in a tertiary care center.
This was a prospective audit focused on administering high doses of NET in female adolescents with complaints of AUB.
We included female adolescents who presented to our Emergency Gynecological Department or Adolescent Gynecological Outpatient Department from October 2016 to January 2019.
The study included 29 female adolescents aged 11-17 (mean, 13.14) years.
Patients were administered a daily dose of 10-30 mg, depending on the severity of the condition, bleeding duration, and patient weight.
Main Outcome Measures
Cessation of vaginal bleeding.
Mean age at menarche of our patient sample was 11.4 years (range, 10.7-14 years). AUB presented at a mean time of 24.6 months after menarche (range, 0-79 months). Blood transfusion was deemed necessary in 9 patients. Bleeding stopped at a mean of 46.1 (range, 8-120) hours after onset of treatment with NET. No serious adverse events were reported with NET administration, with only 3 cases of minor side effects.
The use of NET is an effective and reliable treatment option among adolescents for whom control of AUB is desired in the acute setting.
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Published online: September 11, 2019
The authors indicate no conflicts of interest.
© 2019 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
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- Letter to the Editor: “The Use of Norethisterone for the Treatment of Severe Uterine Bleeding in Adolescents: An Audit of Our Experience”Journal of Pediatric and Adolescent GynecologyVol. 33Issue 3
- PreviewWe read the article by Papapanagiotou et al.1 concerning the treatment of abnormal uterine bleeding (AUB) using norethisterone (NET) with great interest. As the authors state, AUB is an important problem during adolescence and can be underreported until it causes symptomatic anemia. Due to the limited number of studies concerning the use of NET in adolescent girls for AUB, we believe this study is of importance, but we have concerns about why the authors have chosen NET as a first-line standard therapy for all AUB patients.