Abstract
Background
We describe a rare paratubal serous borderline tumor occurring in an adolescent and
provide insight into its molecular underpinnings.
Case
A 14-year-old girl presented with irregular menstrual cycles and a large right pelvic
mass. Computed tomography imaging revealed a cystic neoplasm arising from the right
ovary with peripheral calcification. During laparotomy, a cystic tumor located at
the right parametrium independent of the fallopian tube was identified. The ovary
was intact and the tumor was successfully removed. Intraoperative diagnosis using
the frozen section technique and subsequent pathology revealed a paratubal serous
borderline tumor. Molecular analyses revealed a chromosomally stable tumor genome
and a pathogenic somatic mutation (c.1799 T > A, p.Val600Glu) in the B-Raf proto-oncogene,
serine/threonine kinase (BRAF) gene.
Summary and Conclusion
This case shows that the BRAF p.Val600Glu mutation likely acts as an oncogenic driver in this rare neoplasm.
Key Words
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Article info
Publication history
Published online: November 11, 2020
Footnotes
The authors indicate no conflicts of interest.
Identification
Copyright
© 2021 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc.
