Editorial| Volume 35, ISSUE 3, P267-269, June 2022

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Sexually Transmitted Infection Treatment Guidelines for Adolescent Health Providers: What's New in 2021?

  • Cynthia Holland-Hall
    Address correspondence to: Cynthia Holland-Hall, MD, MPH, Adolescent Medicine, 700 Children's Drive, Suite LA5E, Columbus, OH 43205; Phone (614)722-2493; Fax (614)355-3583
    Associate Professor of Pediatrics, The Ohio State University College of Medicine, Division of Adolescent Medicine, Nationwide Children's Hospital, Columbus, Ohio
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Published:January 11, 2022DOI:


      The Centers for Disease Control and Prevention's Sexually Transmitted Infections Treatment Guidelines, 2021 contain new recommendations for the treatment of gonococcal, chlamydial, and trichomonas infections, as well as pelvic inflammatory disease. Providers are encouraged to broaden their screening practices by considering incorporating rectal and pharyngeal testing when indicated, as well as opt-out testing for adolescent females. The discussion of testing and counseling for genital herpes infections has been expanded.

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        • Centers for Disease Control and Prevention
        Sexually Transmitted Disease Surveillance 2019.
        US Department of Health and Human Services, Atlanta2021
        • Workowski KA
        • Bachman LH
        • Chan PA
        • et al.
        Sexually Transmitted Infections Treatment Guidelines, 2021.
        Morb Mortal Wkly Recomm Rep. 2021; 70: 1-187
        • Páez-Canro C
        • Alzate JP
        • González LM
        • et al.
        Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women.
        Cochrane Database Syst Rev. 2019; 1CD010871
        • Dukers-Muijrers NHTM
        • Wolffs PFG
        • De Vries H
        • et al.
        Treatment effectiveness of azithromycin and doxycycline in uncomplicated rectal and vaginal Chlamydia trachomatis infections in women: a multicenter observational study (FemCure).
        Clin Infect Dis. 2019; 69: 1946
        • Foschi C
        • Zagarrigo M
        • Belletti M
        • et al.
        Genital and extra-genital Chlamydia trachomatis and Neisseria gonorrhoeae infections in young women attending a sexually transmitted infections (STI) clinic.
        New Microbiol. 2020; 43: 115
        • Wiesenfeld HC
        • Meyn LA
        • Darville T
        • et al.
        A randomized controlled trial of ceftriaxone and doxycycline, with or without metronidazole, for the treatment of acute pelvic inflammatory disease.
        Clin Infect Dis. 2021; 72: 1181
        • Kissinger P
        • Muzny CA
        • Mena LA
        • et al.
        Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial.
        Lancet Infect Dis. 2018; 18: 1251
        • Yousuf W
        • Ibrahim H
        • Harfouche M
        • et al.
        Herpes simplex virus type 1 in Europe: systematic review, meta-analyses and meta-regressions.
        BMJ Glob Health. 2020; 5e002388
        • Corey L
        • Wald A
        • Patel R
        • et al.
        Once-daily valacyclovir to reduce the risk of transmission of genital herpes.
        N Engl J Med. 2004; 350: 11
        • Johnston C
        • Magaret A
        • Stern M
        • et al.
        Natural history of genital and oral herpes simplex virus-1 (HSV-1) shedding after first episode genital HSV-1 infection.
        Sex Transm Infect. 2019; 95: A42
        • Smith JS
        • Bailey RC
        • Westreich DJ
        • et al.
        Herpes simplex virus type 2 antibody detection performance in Kisumu, Kenya, using the Herpeselect ELISA, Kalon ELISA, Western blot and inhibition testing.
        Sex Transm Infect. 2009; 85: 92
        • Schwebke JR
        • Marrazzo J
        • Beelen AP
        • et al.
        A phase 3, multicenter, randomized, double-blind, vehicle-controlled study evaluating the safety and efficacy of metronidazole vaginal gel 1.3% in the treatment of bacterial vaginosis.
        Sex Transm Dis. 2015; 42: 376
        • Faro S
        • Skokos CK
        The efficacy and safety of a single dose of Clindesse vaginal cream versus a seven-dose regimen of Cleocin vaginal cream in patients with bacterial vaginosis.
        Infect Dis Obstet Gynecol. 2005; 13: 155