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The Association between Childhood Adversity and Risk of Dysmenorrhea, Pelvic Pain, and Dyspareunia in Adolescents and Young Adults: A Systematic Review

  • Dehlia Moussaoui
    Correspondence
    Address correspondence to: Dr. Dehlia Moussaoui, Department of Paediatric and Adolescent Gynaecology, The Royal Children's Hospital Melbourne, 50 Flemington Road, Parkville 3052, Victoria, Australia.
    Affiliations
    Department of Paediatric and Adolescent Gynaecology, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
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  • Sonia Regina Grover
    Affiliations
    Department of Paediatric and Adolescent Gynaecology, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia

    Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Search for articles by this author

      ABSTRACT

      Purpose

      Exposure to adverse childhood experiences (ACEs) has been associated with poor health outcomes, including chronic pain. However, little is known about the potential impact on the development of pelvic pain in adolescents and young adults. This systematic review was conducted to explore the association between ACEs and dysmenorrhea, pelvic pain, and dyspareunia in adolescents and young adults.

      Methods

      Medline, Embase, and PsycNET were searched, using keywords related to childhood adversity, dysmenorrhea, pelvic pain, and dyspareunia.

      Results

      Of the 566 articles identified, 19 studies were included. There was an association between the number and severity of ACEs and the risk of dysmenorrhea. Sexual abuse and posttraumatic stress disorder appeared to be associated with dysmenorrhea, pelvic pain, and dyspareunia, but it was unclear whether this relationship was mediated by poorer mental health. No association was found for immigration and bullying, and findings were inconsistent regarding female genital mutilation, parental separation, and parental death.

      Conclusions

      Future research should include longitudinal follow-up and use validated tools to assess childhood adversity. A greater understanding of the risk of ACEs among adolescents and young adults with dysmenorrhea, chronic pelvic pain, and dyspareunia could provide insight into the development of these conditions.

      Key Words

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      References

        • Felitti VJ
        • Anda RF
        • Nordenberg D
        • et al.
        Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults.
        Am J Prev Med. 1998; 14: 245-258
        • Turner HA
        • Finkelhor D
        • Mitchell KJ
        • et al.
        Strengthening the predictive power of screening for adverse childhood experiences (ACEs) in younger and older children.
        Child Abuse Negl. 2020; 107104522
        • Merrick MT
        • Ford DC
        • Ports KA
        • et al.
        Vital signs: estimated proportion of adult health problems attributable to adverse childhood experiences and implications for prevention - 25 states, 2015-2017.
        Morb Mortal Wkly Rep. 2019; 68: 999-1005
        • Hughes K
        • Bellis MA
        • Hardcastle KA
        • et al.
        The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis.
        Lancet Public Health. 2017; 2: e356-e366
        • Groenewald CB
        • Murray CB
        • Palermo TM:
        Adverse childhood experiences and chronic pain among children and adolescents in the United States.
        PR9. 2020; 5: e839
        • Schrepf A
        • Naliboff B
        • Williams DA
        • et al.
        Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study.
        Ann Behav Med. 2018; 52: 865-877
        • Raja SN
        • Carr DB
        • Cohen M
        • et al.
        The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises.
        Pain. 2020; 161: 1976-1982
        • Waller R
        • Smith AJ
        • OʼSullivan PB
        • et al.
        The association of early life stressors with pain sensitivity and pain experience at 22 years.
        Pain. 2020; 161: 220-229
        • Iacovides S
        • Avidon I
        • Baker FC:
        What we know about primary dysmenorrhea today: a critical review.
        Hum Reprod Update. 2015; 21: 762-778
        • Hu Z
        • Tang L
        • Chen L
        • et al.
        Prevalence and risk factors associated with primary dysmenorrhea among Chinese female university students: a cross-sectional study.
        J Pediatr Adolesc Gynecol. 2020; 33: 15-22
        • Armour M
        • Ferfolja T
        • Curry C
        • et al.
        The prevalence and educational impact of pelvic and menstrual pain in Australia: a national online survey of 4202 young women aged 13-25 years.
        J Pediatr Adolesc Gynecol. 2020; 33: 511-518
        • Azlan A
        • Salamonsen LA
        • Hutchison J
        • et al.
        Endometrial inflammasome activation accompanies menstruation and may have implications for systemic inflammatory events of the menstrual cycle.
        Hum Reprod. 2020; 35: 1363-1376
        • Janssen EB
        • Rijkers ACM
        • Hoppenbrouwers K
        • et al.
        Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review.
        Hum Reprod Update. 2013; 19: 570-582
        • Kuznetsov L
        • Dworzynski K
        • Davies M
        • et al.
        Diagnosis and management of endometriosis: summary of NICE guidance.
        BMJ. 2017; 358: j3935
        • Vercellini P
        • Fedele L
        • Aimi G
        • et al.
        Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients.
        Hum Reprod. 2007; 22: 266-271
        • Bafort C
        • Beebeejaun Y
        • Tomassetti C
        • et al.
        Laparoscopic surgery for endometriosis.
        Cochrane Database Syst Rev. 2020; : 2020
        • Conroy I
        • Mooney SS
        • Kavanagh S
        • et al.
        Pelvic pain: what are the symptoms and predictors for surgery, endometriosis and endometriosis severity.
        Aust N Z J Obstet Gynaecol. 2021; 61: 765-772
        • Surrey E
        • Carter CM
        • Soliman AM
        • et al.
        Patient-completed or symptom-based screening tools for endometriosis: a scoping review.
        Arch Gynecol Obstet. 2017; 296: 153-165
        • Nur Azurah AG
        • Sanci L
        • Moore E
        • et al.
        The quality of life of adolescents with menstrual problems.
        J Pediatr Adolesc Gynecol. 2013; 26: 102-108
        • Krantz TE
        • Andrews N
        • Petersen TR
        • et al.
        Adverse childhood experiences among gynecology patients with chronic pelvic pain.
        Obstet Gynecol. 2019; 134: 1087-1095
        • Latthe P
        • Mignini L
        • Gray R
        • et al.
        Factors predisposing women to chronic pelvic pain: systematic review.
        BMJ. 2006; 332: 749-755
        • Yosef A
        • Allaire C
        • Williams C
        • et al.
        Multifactorial contributors to the severity of chronic pelvic pain in women.
        Am J Obstet Gynecol. 2016; 215: 760.e1-760.e14
      1. World Health Organization: Female Genital Mutilation. 2020

      2. Wells GA, Shea B, O'Connell S, et al: The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. 2000.

        • Herzog R
        • Álvarez-Pasquin MJ
        • Díaz C
        • et al.
        Are healthcare workers’ intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review.
        BMC Public Health. 2013; 13: 154
        • You DS
        • Albu S
        • Lisenbardt H
        • et al.
        Cumulative childhood adversity as a risk factor for common chronic pain conditions in young adults.
        Pain Med. 2019; 20: 486-494
        • Wenzel SL
        • Hambarsoomian K
        • D'Amico EJ
        • et al.
        Victimization and health among indigent young women in the transition to adulthood: a portrait of need.
        J Adolesc Health. 2006; 38: 536-543
        • Ambresin A-E
        • Belanger RE
        • Chamay C
        • et al.
        Body dissatisfaction on top of depressive mood among adolescents with severe dysmenorrhea.
        J Pediatr Adolesc Gynecol. 2012; 25: 19-22
        • Romito P
        • Cedolin C
        • Bastiani F
        • et al.
        Sexual harassment and menstrual disorders among Italian university women: a cross-sectional observational study.
        Scand J Public Health. 2017; 45: 528-535
        • Santerre-Baillargeon M
        • Vézina-Gagnon P
        • Daigneault I
        • et al.
        Anxiety mediates the relation between childhood sexual abuse and genito-pelvic pain in adolescent girls.
        J Sex Marital Ther. 2017; 43: 774-785
        • Landry T
        • Bergeron S:
        Biopsychosocial factors associated with dyspareunia in a community sample of adolescent girls.
        Arch Sex Behav. 2011; 40: 877-889
        • Ali HAAEW
        • Arafa AE
        • El Fattah Abd Allah
        • Shehata NA
        • et al.
        Prevalence of female circumcision among young women in Beni-Suef, Egypt: a cross-sectional study.
        J Pediatr Adolesc Gynecol. 2018; 31: 571-574
        • Shiferaw MT
        • Wubshet M
        • Tegabu D:
        Menstrual problems and associated factors among students of Bahir Dar University, Amhara National Regional State, Ethiopia: a cross-sectional survey.
        Pan Afr Med J. 2014; 17: 246
        • Azagew AW
        • Kassie DG
        • Walle TA:
        Prevalence of primary dysmenorrhea, its intensity, impact and associated factors among female students’ at Gondar town preparatory school, Northwest Ethiopia.
        BMC Women's Health. 2020; 20: 5
        • Arafa AE
        • Elbahrawe RS
        • Shawky SM
        • et al.
        Epidemiological and gynecological correlates with female genital mutilation among Beni-Suef University students; cross sectional study.
        Middle East Fertil Soc J. 2018; 23: 184-188
        • Shehata NAA
        • Arafa AE
        • El Wahed HAA
        • et al.
        Epidemiology of dysmenorrhea among university students in Egypt.
        Int J Womens Health Wellness. 2018; 4: 073
        • Takeda T
        • Tadakawa M
        • Koga S
        • et al.
        Relationship between dysmenorrhea and posttraumatic stress disorder in Japanese high school students 9 months after the Great East Japan Earthquake.
        J Pediatr Adolesc Gynecol. 2013; 26: 355-357
        • Seng JS:
        Posttraumatic stress disorder and physical comorbidity among female children and adolescents: results from service-use data.
        Pediatrics. 2005; 116: e767-e776
        • Du Y
        • Knopf H
        • Zhuang W
        • et al.
        Pain perceived in a national community sample of German children and adolescents.
        Eur J Pain. 2011; 15: 649-657
        • Seltzer MB
        • Long RA:
        Bullying in an adolescent and young adult gynecology population.
        Clin Pediatr (Phila). 2013; 52: 156-161
        • Wong LP
        • Khoo EM:
        Dysmenorrhea in a multiethnic population of adolescent Asian girls.
        Int J Gynecol Obstet. 2010; 108: 139-142
        • Wadhwa L
        • Sharma JB
        • Arora R
        • et al.
        Severity, affect, family and environment (SAFE) approach to evaluate chronic pelvic pain in adolescent girls.
        Indian J Med Sci. 2004; 58: 275-282
        • Gagua T
        • Tkeshelashvili B
        • Gagua D
        • et al.
        Assessment of anxiety and depression in adolescents with primary dysmenorrhea: a case-control study.
        J Pediatr Adolesc Gynecol. 2013; 26: 350-354
        • Xu K
        • Chen L
        • Fu L
        • et al.
        Stressful parental-bonding exaggerates the functional and emotional disturbances of primary dysmenorrhea.
        Int J Behav Med. 2016; 23: 458-463
        • Hoppenbrouwers K
        • Roelants M
        • Meuleman C
        • et al.
        Characteristics of the menstrual cycle in 13-year-old Flemish girls and the impact of menstrual symptoms on social life.
        Eur J Pediatr. 2016; 175: 623-630
        • Parker M
        • Sneddon A
        • Arbon P:
        The menstrual disorder of teenagers (MDOT) study: determining typical menstrual patterns and menstrual disturbance in a large population-based study of Australian teenagers: the MDOT study.
        BJOG: Int J Obstet Gynaecol. 2010; 117: 185-192
        • Li R
        • Kreher DA
        • Jusko TA
        • et al.
        Prospective association between dysmenorrhea and chronic pain development in community-dwelling women.
        J Pain. 2021; 22: 1084-1096
        • Nelson SM
        • Cunningham NR
        Kashikar-Zuck SA: Conceptual framework for understanding the role of adverse childhood experiences in pediatric chronic pain.
        Clin J Pain. 2017; 33: 264-270
        • Shalev I
        • Moffitt TE
        • Sugden K
        • et al.
        Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study.
        Mol Psychiatry. 2013; 18: 576-581
        • Chatterjee N:
        Stress runs deep and long: identification of molecular biomarkers of childhood stress in adults.
        BioEssays. 2018; 401800126
        • Miller GE
        • Chen E
        • Parker KJ”
        Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms.
        Psychol Bull. 2011; 137: 959-997
        • Fagundes CP
        • Glaser R
        • Kiecolt-Glaser JK:
        Stressful early life experiences and immune dysregulation across the lifespan.
        Brain Behav Immun. 2013; 27: 8-12
        • Heim C
        • Newport DJ
        • Heit S
        • et al.
        Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.
        JAMA. 2000; 284: 592-597
        • Southwick SM
        • Bonanno GA
        • Masten AS
        • et al.
        Resilience definitions, theory, and challenges: interdisciplinary perspectives.
        Eur J Psychotraumatol. 2014; 5
        • Ashby BD
        • Ehmer AC
        • Scott SM:
        Trauma-informed care in a patient-centered medical home for adolescent mothers and their children.
        Psychol Serv. 2019; 16: 67-74