ABSTRACT
Study Objectives
To characterize the skeletal, cardiometabolic, cognitive, and mental health phenotype
of adolescents with idiopathic premature ovarian insufficiency (POI)
Design
Case control
Setting
Pediatric tertiary referral center in Cincinnati, Ohio
Participants
Nine adolescents (ages 11-18.99 years) with newly diagnosed POI and 9 normally menstruating
controls, matched by age and body mass index
Main Outcome Measures
Between-group comparisons of bone characteristics assessed by dual energy x-ray absorptiometry
(DXA) and peripheral quantitative computed tomography (pQCT), psychosocial health
(anxiety, depression, and quality of life), and cognition and memory by questionnaire
Results
Adolescents with POI had lower bone density Z-scores by DXA (lumbar spine −1.93 vs
0.80; whole body less head −2.05 vs 0.00; total hip −1.03 vs 0.83; and femoral neck
−1.23 vs 0.91; all P < .001), as well as lower trabecular volumetric bone mineral density (tibia 3% site
226 vs 288 mg/mm3, P < .001; radius 3% site 200 vs 251, P = .001), smaller cortical area (tibia 66% site 251 vs 292 mm2, P = .028), and thickness (tibia 66% site 3.56 vs 4.30 mm, P = .001) than controls. No abnormalities in cardiometabolic biomarkers were detected
in POI cases. Adolescents with POI were also more likely to report low energy (78%
vs 22%, P = .02).
Conclusion
Estrogen deficiency adversely affects bone health in adolescents with POI. However,
we did not find associations with cardiometabolic, mental health, or cognitive outcomes
in this small sample.
Key Words
Abbreviations:
BMD (bone mineral density), POI (premature ovarian insufficiency)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 06, 2022
Accepted:
October 1,
2022
Received in revised form:
September 12,
2022
Received:
March 21,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Supporting Grants: Extramural grant support from the Patty Brisben Foundation for Women's Sexual Health
Results Presented At: Pediatric Endocrine Society, Virtual Meeting, May 1, 2022, and International Conference for Childhood Bone Health, Dublin, Ireland, July 3, 2022
Identification
Copyright
© 2022 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
