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Recurrence Rates for Pediatric Benign Ovarian Neoplasms

Published:December 07, 2022DOI:https://doi.org/10.1016/j.jpag.2022.11.006

      Abstract

      Study Objective

      To examine the recurrence rates of pediatric benign ovarian neoplasms

      Methods

      A retrospective review of females up to 21 years of age who underwent surgery for a benign ovarian neoplasm at 8 pediatric hospitals from January 2010 through December 2016 was conducted. Data include primary operation details, follow-up imaging, and reoperation details.

      Results

      Four hundred and twenty-six females were included in our cohort, with a median age of 15 years at the time of the primary operation. Of the patients, 69% had a mature teratoma, 18% had a serous cystadenoma, and 8% had a mucinous cystadenoma. Two-thirds of patients underwent ovarian-sparing surgery. There were 11 pathologically confirmed recurrences (2.6%) at a median follow-up of 12.8 months. The pathologically confirmed recurrence was 10.5 per 100 person-months at 12 months (SE = 5.7) for mucinous cystadenomas and 0.4 months (SE = 0.4) for mature teratomas (P = .001). For half of the patients, the pathologically confirmed recurrences occurred by 12.8 months, and for 75%, they occurred by 23.3 months. There were no differences in reoperation or recurrence on the basis of initial procedure (ovary-sparing surgery vs oophorectomy).

      Conclusion

      We measured the pathologically confirmed recurrence rate for pediatric benign ovarian neoplasms in a large cohort. Oophorectomy was not protective against recurrence. Mucinous cystadenomas were at a greater risk of pathologically confirmed recurrence.

      Key Words

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      References

        • Hermans AJ
        • Kluivers KB
        • Wijnen MH
        • et al.
        Diagnosis and treatment of adnexal masses in children and adolescents.
        Obstet Gynecol. 2015; 125: 611-615
        • Zhang M
        • Jiang W
        • Li G
        • Xu C
        Ovarian masses in children and adolescents - an analysis of 521 clinical cases.
        J Pediatr Adolesc Gynecol. 2014; 27: e73-e77
        • Taskinen S
        • Fagerholm R
        • Lohi J
        • Taskinen M
        Pediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome.
        Acta Obstet Gynecol Scand. 2015; 94: 425-429
        • Cass DL
        • Hawkins E
        • Brandt ML
        • et al.
        Surgery for ovarian masses in infants, children, and adolescents: 102 consecutive patients treated in a 15-year period.
        J Pediatr Surg. 2001; 36: 693-699
        • Skinner MA
        • Schlatter MG
        • Heifetz SA
        • Grosfeld JL
        Ovarian neoplasms in children.
        Arch Surg. 1993; 128: 849-854
        • Lawrence AE
        • Gonzalez DO
        • Fallat ME
        • et al.
        Factors associated with management of pediatric ovarian neoplasms.
        Pediatrics. 2019; 144e20182537
        • Karpelowsky JS
        • Hei ER
        • Matthews K
        Laparoscopic resection of benign ovarian tumours in children with gonadal preservation.
        Pediatr Surg Int. 2009; 25: 251-254
        • Chabaud-Williamson M
        • Netchine I
        • Fasola S
        • et al.
        Ovarian-sparing surgery for ovarian teratoma in children.
        Pediatr Blood Cancer. 2011; 57: 429-434
        • Abbas PI
        • Dietrich JE
        • Francis JA
        • et al.
        Ovarian-sparing surgery in pediatric benign ovarian tumors.
        J Pediatr Adolesc Gynecol. 2016; 29: 506-510
        • Lawrence AE
        • Minneci PC
        • Deans KJ
        Ovary-sparing surgery for benign pediatric ovarian masses.
        Curr Opin Pediatr. 2019; 31: 386-390
        • Özcan R
        • Kuruoğlu S
        • Dervişoğlu S
        • et al.
        Ovary-sparing surgery for teratomas in children.
        Pediatr Surg Int. 2013; 29: 233-237
        • Agarwal P
        • Agarwal P
        • Bagdi R
        • et al.
        Ovarian preservation in children for adenexal pathology, current trends in laparoscopic management and our experience.
        J Indian Assoc Pediatr Surg. 2014; 19: 65-69
        • Lind T
        • Holte J
        • Olofsson JI
        • et al.
        Reduced live-birth rates after IVF/ICSI in women with previous unilateral oophorectomy: results of a multicentre cohort study.
        Hum Reprod. 2018; 33: 238-247
        • Rocca WA
        • Bower JH
        • Maraganore DM
        • et al.
        Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause.
        Neurology. 2007; 69: 1074-1083
        • Yasui T
        • Hayashi K
        • Mizunuma H
        • et al.
        Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women.
        Maturitas. 2012; 72: 249-255
        • Al Jama FE
        • Al Ghamdi AA
        • Gasim T
        • et al.
        Ovarian tumors in children and adolescents—a clinical study of 52 patients in a university hospital.
        J Pediatr Adolesc Gynecol. 2011; 24: 25-28
        • De Backer A
        • Madern GC
        • Oosterhuis JW
        • et al.
        Ovarian germ cell tumors in children: a clinical study of 66 patients.
        Pediatr Blood Cancer. 2006; 46: 459-464
        • Massicot R
        • Rousseau V
        • Darwish AA
        • et al.
        Serous and seromucinous infantile ovarian cystadenomas—a study of 42 cases.
        Eur J Obstet Gynecol Reprod Biol. 2009; 142: 64-67
        • Rogers EM
        • Allen L
        • Kives S
        The recurrence rate of ovarian dermoid cysts in pediatric and adolescent girls.
        J Pediatr Adolesc Gynecol. 2014; 27: 222-226
        • Childress KJ
        • Santos XM
        • Perez-Milicua G
        • et al.
        Intraoperative rupture of ovarian dermoid cysts in the pediatric and adolescent population: should this change your surgical management?.
        J Pediatr Adolesc Gynecol. 2017; 30: 636-640
        • Taskinen S
        • Urtane A
        • Fagerholm R
        • et al.
        Metachronous benign ovarian tumors are not uncommon in children.
        J Pediatr Surg. 2014; 49: 543-545
        • Templeman CL
        • Hertweck SP
        • Scheetz JP
        • et al.
        The management of mature cystic teratomas in children and adolescents: a retrospective analysis.
        Hum Reprod. 2000; 15: 2669-2672
        • Fujishima A
        • Kumazawa Y
        • Togashi K
        • et al.
        A case of ovarian mucinous cystadenoma in a child that recurred 1 year after surgery.
        Int J Surg Case Rep. 2021; 83106006
        • Ben-Ami I
        • Smorgick N
        • Tovbin J
        • et al.
        Does intraoperative spillage of benign ovarian mucinous cystadenoma increase its recurrence rate?.
        Am J Obstet Gynecol. 2010; 202 (142.e141-145)
        • Braungart S
        • Craigie RJ
        • Farrelly P
        • Losty PD
        Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study.
        J Pediatr Surg. 2020; 55: 2026-2029
        • Knaus ME
        • Onwuka AJ
        • Afrazi A
        • et al.
        Laparoscopy versus laparotomy for pediatric ovarian dermoids.
        J Pediatr Surg. 2022; 57: 1008-1012
        • Sri Paran T
        • Mortell A
        • Devaney D
        • et al.
        Mucinous cystadenoma of the ovary in perimenarchal girls.
        Pediatr Surg Int. 2006; 22: 224-227
        • Cowan RA
        • Haber EN
        • Faucz FR
        • et al.
        Mucinous cystadenoma in children and adolescents.
        J Pediatr Adolesc Gynecol. 2017; 30: 495-498
        • Mizrachi Y
        • Weiner E
        • Keidar R
        • et al.
        Intraoperative rupture of benign mucinous cystadenoma does not increase its recurrence rate.
        Arch Gynecol Obstet. 2015; 291: 1135-1139