Abstract
Study Objective
To examine the recurrence rates of pediatric benign ovarian neoplasms
Methods
A retrospective review of females up to 21 years of age who underwent surgery for
a benign ovarian neoplasm at 8 pediatric hospitals from January 2010 through December
2016 was conducted. Data include primary operation details, follow-up imaging, and
reoperation details.
Results
Four hundred and twenty-six females were included in our cohort, with a median age
of 15 years at the time of the primary operation. Of the patients, 69% had a mature
teratoma, 18% had a serous cystadenoma, and 8% had a mucinous cystadenoma. Two-thirds
of patients underwent ovarian-sparing surgery. There were 11 pathologically confirmed
recurrences (2.6%) at a median follow-up of 12.8 months. The pathologically confirmed
recurrence was 10.5 per 100 person-months at 12 months (SE = 5.7) for mucinous cystadenomas
and 0.4 months (SE = 0.4) for mature teratomas (P = .001). For half of the patients, the pathologically confirmed recurrences occurred
by 12.8 months, and for 75%, they occurred by 23.3 months. There were no differences
in reoperation or recurrence on the basis of initial procedure (ovary-sparing surgery
vs oophorectomy).
Conclusion
We measured the pathologically confirmed recurrence rate for pediatric benign ovarian
neoplasms in a large cohort. Oophorectomy was not protective against recurrence. Mucinous
cystadenomas were at a greater risk of pathologically confirmed recurrence.
Key Words
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References
- Diagnosis and treatment of adnexal masses in children and adolescents.Obstet Gynecol. 2015; 125: 611-615
- Ovarian masses in children and adolescents - an analysis of 521 clinical cases.J Pediatr Adolesc Gynecol. 2014; 27: e73-e77
- Pediatric ovarian neoplastic tumors: incidence, age at presentation, tumor markers and outcome.Acta Obstet Gynecol Scand. 2015; 94: 425-429
- Surgery for ovarian masses in infants, children, and adolescents: 102 consecutive patients treated in a 15-year period.J Pediatr Surg. 2001; 36: 693-699
- Ovarian neoplasms in children.Arch Surg. 1993; 128: 849-854
- Factors associated with management of pediatric ovarian neoplasms.Pediatrics. 2019; 144e20182537
- Laparoscopic resection of benign ovarian tumours in children with gonadal preservation.Pediatr Surg Int. 2009; 25: 251-254
- Ovarian-sparing surgery for ovarian teratoma in children.Pediatr Blood Cancer. 2011; 57: 429-434
- Ovarian-sparing surgery in pediatric benign ovarian tumors.J Pediatr Adolesc Gynecol. 2016; 29: 506-510
- Ovary-sparing surgery for benign pediatric ovarian masses.Curr Opin Pediatr. 2019; 31: 386-390
- Ovary-sparing surgery for teratomas in children.Pediatr Surg Int. 2013; 29: 233-237
- Ovarian preservation in children for adenexal pathology, current trends in laparoscopic management and our experience.J Indian Assoc Pediatr Surg. 2014; 19: 65-69
- Reduced live-birth rates after IVF/ICSI in women with previous unilateral oophorectomy: results of a multicentre cohort study.Hum Reprod. 2018; 33: 238-247
- Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause.Neurology. 2007; 69: 1074-1083
- Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women.Maturitas. 2012; 72: 249-255
- Ovarian tumors in children and adolescents—a clinical study of 52 patients in a university hospital.J Pediatr Adolesc Gynecol. 2011; 24: 25-28
- Ovarian germ cell tumors in children: a clinical study of 66 patients.Pediatr Blood Cancer. 2006; 46: 459-464
- Serous and seromucinous infantile ovarian cystadenomas—a study of 42 cases.Eur J Obstet Gynecol Reprod Biol. 2009; 142: 64-67
- The recurrence rate of ovarian dermoid cysts in pediatric and adolescent girls.J Pediatr Adolesc Gynecol. 2014; 27: 222-226
- Intraoperative rupture of ovarian dermoid cysts in the pediatric and adolescent population: should this change your surgical management?.J Pediatr Adolesc Gynecol. 2017; 30: 636-640
- Metachronous benign ovarian tumors are not uncommon in children.J Pediatr Surg. 2014; 49: 543-545
- The management of mature cystic teratomas in children and adolescents: a retrospective analysis.Hum Reprod. 2000; 15: 2669-2672
- A case of ovarian mucinous cystadenoma in a child that recurred 1 year after surgery.Int J Surg Case Rep. 2021; 83106006
- Does intraoperative spillage of benign ovarian mucinous cystadenoma increase its recurrence rate?.Am J Obstet Gynecol. 2010; 202 (142.e141-145)
- Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study.J Pediatr Surg. 2020; 55: 2026-2029
- Laparoscopy versus laparotomy for pediatric ovarian dermoids.J Pediatr Surg. 2022; 57: 1008-1012
- Mucinous cystadenoma of the ovary in perimenarchal girls.Pediatr Surg Int. 2006; 22: 224-227
- Mucinous cystadenoma in children and adolescents.J Pediatr Adolesc Gynecol. 2017; 30: 495-498
- Intraoperative rupture of benign mucinous cystadenoma does not increase its recurrence rate.Arch Gynecol Obstet. 2015; 291: 1135-1139
Article info
Publication history
Published online: December 07, 2022
Accepted:
November 28,
2022
Received in revised form:
November 10,
2022
Received:
July 25,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.
